B6506
Benzamidine hydrochloride hydrate
≥99%
동의어(들):
Amidinobenzene hydrochloride, Benzamidinium chloride, Benzenecarboximidamide hydrochloride
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
C6H5C(=NH)NH2 · HCl · xH2O
CAS 번호:
Molecular Weight:
156.61 (anhydrous basis)
UNSPSC Code:
12352107
NACRES:
NA.77
PubChem Substance ID:
EC Number:
216-795-4
Beilstein/REAXYS Number:
3594959
MDL number:
InChI key
BQVJCMMLDJPBFZ-UHFFFAOYSA-N
InChI
1S/C7H8N2.ClH.H2O/c8-7(9)6-4-2-1-3-5-6;;/h1-5H,(H3,8,9);1H;1H2
SMILES string
Cl[H].[H]O[H].NC(=N)c1ccccc1
biological source
synthetic (organic)
assay
≥99%
form
powder
mp
86-88 °C (lit.)
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
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Application
Benzamidine hydrochloride hydrate has been used:
- in western blot analysis
- in immunoprecipitation
- in the purification of yeast dynein
- as a protease inhibitor in the preparation of brush-border membrane vesicles
- for the processing of human synovial fluid, blood and eye sleep
- to prevent non-specific degradation of cartilages
Biochem/physiol Actions
Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
Peptidase inhibitor.
Preparation Note
Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Sialidase unmasks mucin domain epitopes of lubricin
Solka KA, et al.
The Journal of Histochemistry and Cytochemistry, 64(11), 647-668 (2016)
Contrast-enhanced CT using a cationic contrast agent enables non-destructive assessment of the biochemical and biomechanical properties of mouse tibial plateau cartilage
Lakin BA, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 34(7), 1130-1138 (2016)
Contrast-enhanced CT imaging as a non-destructive tool for ex vivo examination of the biochemical content and structure of the human meniscus
Oh DJ, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 35(5), 1018-1028 null
The MDM2 RING and central acidic domains play distinct roles in MDM2 homodimerization and MDM2-MDMX heterodimerization
Leslie PL, et al
The Journal of biological chemistry, 6(51), jbc-M115 (2015)
Combining Structure-Function and Single-Molecule Studies on Cytoplasmic Dynein
Single Molecule Analysis, 53-89 (2018)
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