P1004
Polymyxin B sulfate salt
동의어(들):
Polymixin, Polymixin B, Polymixin B sulfate
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C55H96N16O13 · 2H2SO4
CAS 번호:
Molecular Weight:
1385.61
UNSPSC Code:
51283106
NACRES:
NA.76
EC Number:
215-774-7
MDL number:
InChI key
HNDFYNOVSOOGDU-UHFFFAOYSA-N
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
SMILES string
O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
biological source
Pseudomonas aeruginosa
form
powder
storage condition
(Tightly closed. Dry. )
solubility
water: 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, fungi
Quality Level
storage temp.
2-8°C
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General description
Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate.
Application
Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Polymyxin B sulfate salt has been used:
- in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin
- in the analysis of the isolates
- in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay)
Biochem/physiol Actions
Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae.
Features and Benefits
High quality antibiotic suitable for mulitple research applications
Preparation Note
As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions.
Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.
Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Biochemical and toxic diversity of Bacillus cereus in a pasta and meat dish associated with a food-poisoning case
Pirhonen T I, et al.
Food Microbiology, 22(1), 87-91 (2005)
Dosing and pharmacokinetics of polymyxin B in patients with renal insufficiency
Thamlikitkul V, et al.
Antimicrobial Agents and Chemotherapy, e01337-e01316 (2017)
Globular adiponectin counteracts VCAM-1-mediated monocyte adhesion via AdipoR1/NF-kappaB/COX-2 signaling in human aortic endothelial cells
Addabbo F, et al.
American Journal of Physiology. Endocrinology and Metabolism, 301(6), E1143-E1143 (2011)
Endotoxin-neutralizing activity and mechanism of action of a cationic alpha-helical antimicrobial octadecapeptide derived from alpha-amylase of rice
Taniguchi M, et al.
Peptides, 101-108 (2016)
Xucheng Huang et al.
International journal of medical microbiology : IJMM, 308(7), 819-828 (2018-07-24)
Ureaplasma spp. are known to be associated with human genitourinary tract diseases and perinatal diseases and Ureaplasma spp. Lipid-associated membrane proteins (LAMPs) play important roles in their related diseases. However, the exact mechanism underlying pathogenesis of Ureaplasma spp. LAMPs is
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