Quality Level
biological source
Porcine (tallow), bovine (tallow)
description
non-ionic
form
viscous liquid
mol wt
micellar avg mol wt 79,000, average mol wt 1310
composition
Oleic acid, ≥58.0% (balance primarily linoleic, palmitic, and stearic acids)
aggregation number
60
CMC
0.012 mM (20-25°C)
viscosity
400-620 mPa.s
transition temp
cloud point 65 °C
solubility
water: soluble, clear to slightly hazy, colorless to yellow
density
1.064 g/cm3
HLB
15
application(s)
advanced drug delivery
cell analysis
SMILES string
CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO
InChI
1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+
InChI key
RGPBUVUVZKQNHD-MDZDMXLPSA-N
General description
Tween® 80 is a non-ionic detergent and surfactant, classified as an ester of sorbitan and oleic acid. It is a versatile compound commonly employed in various biological applications, including cell lysis, nuclei isolation, and cell fractionation. Additionally, Tween 80 finds use in stabilizing proteins and facilitating protein membrane studies. Its effectiveness stems from its membership in the polysorbate group, characterized by the combination of sorbitol and sorbitane oleic esters with polyethylene glycol chains. These structural features contribute to Tween 80′s emulsifying capabilities and a broad range of applications.
Application
Non-ionic detergent used for selective protein extraction and isolation of nuclei from mammalian cell lines.
TWEEN® 80 has been used in drug vehicle solution for specific injections in mice and rats. It has been used for the determination of esterase activity in bacterial cells.
Biochem/physiol Actions
TWEEN® 80 is a polysorbate surfactant which helps in stabilizing proteins and in protein membrane studies. It is regularly used for the extraction of membrane proteins and isolation of nuclei from cells.
Features and Benefits
- Excellent wetting and dispersing agent
- Highly versatile surfactant for your Cell Biology and Biochemical research
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Legal Information
TWEEN is a registered trademark of Croda International PLC
저장 등급
10 - Combustible liquids
flash_point_f
>482.0 °F - Cleveland open cup
flash_point_c
> 250 °C - Cleveland open cup
ppe
Eyeshields, Gloves
HU-210 shows higher efficacy and potency than morphine after intrathecal administration in the mouse formalin test.
Guhring H et al.
European Journal of Pharmacology, 429, 127-127 (2001)
Zandra Gerdes et al.
PloS one, 14(2), e0205378-e0205378 (2019-02-20)
The role of microplastic (MP) as a carrier of persistent organic pollutants (POPs) to aquatic organisms has been a topic of debate. However, the reverse POP transport can occur if relative contaminant concentrations are higher in the organism than in
Yee-Kuen Yam et al.
Frontiers in microbiology, 11, 359-359 (2020-03-21)
Persistence of infection despite extensive chemotherapy with antibiotics displaying low MICs is a hallmark of lung disease caused by Mycobacterium abscessus (Mab). Thus, the classical MIC assay is a poor predictor of clinical outcome. Discovery of more efficacious antibiotics requires