S3674
Succinic acid
BioXtra, BioRenewable, ≥99.0%
동의어(들):
Butanedioic acid
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
HOOCCH2CH2COOH
CAS 번호:
Molecular Weight:
118.09
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
EC Number:
203-740-4
Beilstein/REAXYS Number:
1754069
MDL number:
Assay:
≥99.0%
InChI key
KDYFGRWQOYBRFD-UHFFFAOYSA-N
InChI
1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
SMILES string
OC(=O)CCC(O)=O
product line
BioXtra
assay
≥99.0%
greener alternative product characteristics
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
impurities
≤0.01% Insoluble matter
ign. residue
≤0.02%
bp
235 °C (lit.)
Quality Level
solubility
H2O: 0.5 M, clear, colorless
anion traces
chloride (Cl-): ≤0.001%, sulfate (SO42-): ≤0.003%
cation traces
Al: ≤0.0005%, Ca: ≤0.001%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%
greener alternative category
, Aligned
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General description
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is biobased and thus aligns with "Use of Renewable Feedstocks". Click here for more information.
Application
Succinic acid has been used:
- in succinate dehydrogenase mitochondrial assay.
- as an internal standard in mass spectroscopy.
- as succinate dehydrogenase substrate in oxygraph analysis to measure respiration rates.
Biochem/physiol Actions
Succinic acid is a byproduct of anaerobic fermentation in microbes. It is a dicarboxylic acid and an intermediate in Kreb′s cycle. Polymorphism in succinate dehydrogenase leads to succinate accumulation. High levels of succinate impairs 2-oxoglutarate epigenetic signalling. Succinate levels may modulate tumor progression. Succinate inhibits histone demethylation and may contribute to epigenetic changes. Succinate is crucial for interleukin-1 β (IL-1β) synthesis during inflammation and immune signalling.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Oncometabolites: Unconventional triggers of oncogenic signalling cascades
Sciacovelli M and Frezza C
Free Radical Biology & Medicine, 100(9), 175-181 (2016)
Succinate: a new epigenetic hacker
Yang M and Pollard PJ
Cancer Cell, 23(6), 709-711 (2013)
Cardiomyocyte differentiation: Experience and observations from 2 laboratories
Patten VA, et al.
SA heart journal, 14(2), 96-107 (2017)
Screening For Isolation of Succinic Acid Producing Microbes
Hema N and Sreenath KP
Biosciences, Biotechnology Research Asia, 15(2), 327-333 (2018)
Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue
Whitaker-Menezes D, et al.
Cell Cycle, 10(23), 4047-4064 (2011)
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