345547
Hydrogen chloride solution
4.0 M in dioxane
์กฐ์ง ๋ฐ ๊ณ์ฝ ๊ฐ๊ฒฉ์ ๋ณด๋ ค๋ฉด ๋ก๊ทธ์ธ๋ฅผ ํด๋ฆญํฉ๋๋ค.
ํฌ๊ธฐ ์ ํ
๋ณด๊ธฐ ๋ณ๊ฒฝ
์ ํ์ ๋ณด (DICE ๋ฐฐ์ก ์ ๋น์ฉ ๋ณ๋)
์คํ์(Hill ํ๊ธฐ๋ฒ):
HCl
CAS ๋ฒํธ:
Molecular Weight:
36.46
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352301
MDL number:
Concentration:
3.80-4.40 M (by NaOH, titration), 4.0 M in dioxane
Form:
liquid
๊ธฐ์ ์๋น์ค
๋์์ด ํ์ํ์ ๊ฐ์? ์ ํฌ ์๋ จ๋ ๊ณผํ์ ํ์ด ๋์๋๋ฆฌ๊ฒ ์ต๋๋ค.
๋์ ๋ฌธ์form
liquid
Quality Level
concentration
3.80-4.40 M (by NaOH, titration), 4.0 M in dioxane
density
1.05 g/mL at 25 ยฐC
SMILES string
Cl
InChI
1S/ClH/h1H
InChI key
VEXZGXHMUGYJMC-UHFFFAOYSA-N
General description
Hydrogen chloride solution contains 4.0 M hydrogen chloride in 1,4-dioxane as the solvent. It is commonly used as a deprotection reagent during the deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides. Additionally, it serves as a reagent in various organic synthesis reactions, including the synthesis of N-9-Fluorenylmethoxycarbonyl- (Fmoc) amino-acid chlorides.
Application
Hydrogen chloride solution (4.0 M in dioxane) can be used as:ย ย ย ย ย
- A reagent for the deprotection of the N-Boc protecting group from various heterocyclic derivatives.ย ย ย ย ย
- A reagent for the deprotection of polymer protecting groups. For instance, deprotection of benzyl ether-protected polymer.ย ย ย ย ย ย
- A polymerization initiator in combination with ZnCl2 in the synthesis of formyl terminated poly(ethyl vinyl ether) from ethyl vinyl ether (EVE).
signalword
Danger
Hazard Classifications
Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
supp_hazards
์ ์ฅ ๋ฑ๊ธ
3 - Flammable liquids
flash_point_f
62.6 ยฐF - closed cup
flash_point_c
17 ยฐC - closed cup
๊ฐ์ฅ ์ต์ ๋ฒ์ ์ค ํ๋๋ฅผ ์ ํํ์ธ์:
์ด ์ ํ์ ์ด๋ฏธ ๊ฐ์ง๊ณ ๊ณ์ญ๋๊น?
๋ฌธ์ ๋ผ์ด๋ธ๋ฌ๋ฆฌ์์ ์ต๊ทผ์ ๊ตฌ๋งคํ ์ ํ์ ๋ํ ๋ฌธ์๋ฅผ ์ฐพ์๋ณด์ธ์.
Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group using HCl/dioxane (4 m)
G H, et al.
The Journal of Peptide Research, 4, 338-341 (2001)
Preparation of N-9-fluorenylmethoxycarbonylamino acid chlorides from mixed anhydrides by the action of hydrogen chloride 1
FRANCIS C MF, et al.
International Journal of Peptide and Protein Research, 38, 97-102 (1991)
Surface-and redox-active multifunctional polyphenol-derived poly (ionic liquid) s: controlled synthesis and characterization
Patil N, et al.
Macromolecules, 49(20), 7676-7691 (2016)