282200
Galangin
autophagy inducing flavonoid
동의어(들):
3,5,7-Trihydroxyflavone, Norizalpinin
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H10O5
CAS 번호:
Molecular Weight:
270.24
UNSPSC Code:
41116107
NACRES:
NA.79
PubChem Substance ID:
EC Number:
208-960-4
Beilstein/REAXYS Number:
272179
MDL number:
Quality Segment
assay
≥95% (HPLC)
form
powder
color
yellow
mp
214-215 °C (lit.)
SMILES string
Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
InChI
1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
InChI key
VCCRNZQBSJXYJD-UHFFFAOYSA-N
Gene Information
human ... ADORA2A(135), ADORA3(140), CYP1A2(1544)
rat ... Adora1(29290), Adora2a(25369)
General description
Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.
Application
Galangin has been used:
- as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity
- to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes
- as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy
Biochem/physiol Actions
Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
문서
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.