콘텐츠로 건너뛰기
Merck

42966

12-Hydroxy-octadecanoicacid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl)

동의어(들):

HS 15, Macrogol (15)-hydroxystearate, Polyethylene glycol (15)-hydroxystearate, Polyoxyethylated 12-hydroxystearic acid, Solutol® HS 15

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택


제품정보 (DICE 배송 시 비용 별도)

CAS 번호:
UNSPSC Code:
12161900
PubChem Substance ID:
NACRES:
NA.25
기술 서비스
도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.
도움 문의
기술 서비스
도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.
도움 문의

form

paste

SMILES string

C(CCCCC(CCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O)CCCCC(=O)O

InChI

1S/C47H94O19/c48-15-17-53-19-21-55-23-25-57-27-29-59-31-33-61-35-37-63-39-41-65-43-45-66-44-42-64-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-11-7-6-9-13-46(49)12-8-4-2-1-3-5-10-14-47(50)51/h46,48-49H,1-45H2,(H,50,51)

InChI key

CYAMZYIUAHNTBO-UHFFFAOYSA-N

description

non-ionic

composition

free macrogoly% (27.0 - 39.0 g/100g (%))

impurities

acetic acid (≤ 0.5 g/100g (%)), water (≤ 0.5 g/100g (%)), ≤0.05% acetic acid, ≤0.05% water, ≤1 mg/kg ethylene oxide ((ppm)), ≤1 mg/kg ethylene oxide, ≤1 mg/kg nickel ((ppm)), ≤1 mg/kg nickle, ≤10 mg/kg dioxane ((ppm)), ≤10 mg/kg dioxane, ≤10 mg/kg heavy metals, ≤620 mg/kg Diethylene glycol, ≤620 mg/kg diethylene glycol ((ppm)), ≤620 mg/kg ethylene glycol ((ppm)), ≤620 mg/kg ethylene glycol, <10 mg/kg heavy metals ((ppm))

ign. residue

(≤ 0.3 g/100g (%))

pH

5.0-7.0 (1 g/10 mL in H2O)

mp

25 - 30  °C (77 - 86 °F)

acid value

≤1.0 mg KOH/g

hydroxyl value

90‑110 mg KOH/g

iodine value

≤2.0 g I2/100 g

peroxide value

≤3.0 meq/kg

saponification value

53‑63 mg KOH/g

solubility

water: 200 g/L at 30 °C (86 °F)

density

1.048 g/cm3 at 20 °C (68 °F), 1.03 g/cm3 at 60 °C (140 °F)

anion traces

<1 ppm (Ethylene Oxide), <10 ppm (Dioxane)

cation traces

Ni: <1 ppm, heavy metals: <10 ppm

application(s)

sample preservation

Quality Level

General description

12-Hydroxy-octadecanoicacid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl), a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).

Application

  • 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) has been used:
  • in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle force
  • in roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses
  • to dissolve finerenone for oral application in in vivo-studies

Biochem/physiol Actions

12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is mainly used as a solubilizer in parenteral and oral formulations. It is preferred for in vitro screening and in vivo efficacy studies of compounds. 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is also used in ophthalmic, macromolecule, suppository, and protein formulations due to its solubilization characteristics and safety profiles. It can form micelles typically ranging from 10-15 nm. 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) can be used to develop micro-emulsion IV formulations.

Other Notes

12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is a non-ionic detergent obtained by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxy stearic acid.
For additional information on our range of Biochemicals, please complete this form.

Legal Information

Solutol is a registered trademark of BASF SE

pictograms

Exclamation mark

signalword

Warning

hcodes

pcodes

Hazard Classifications

Skin Sens. 1

저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

521.6 °F

flash_point_c

272 °C


가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

J S Coon et al.
Cancer research, 51(3), 897-902 (1991-02-01)
A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance of KB 8-5 and KB 8-5-11 human epidermoid carcinoma cells in vitro but
Li Gan et al.
International journal of pharmaceutics, 365(1-2), 143-149 (2008-09-09)
The objective of the present study was to design a novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of a lipophilic drug, cyclosporine A (CsA). A CsA-loaded microemulsion was prepared using castor oil, Solutol HS 15 (surfactant), glycerol
Emlyn Clay et al.
The Journal of pharmacology and experimental therapeutics, 357(1), 73-83 (2016-02-04)
Cough remains a major unmet clinical need, and preclinical animal models are not predictive for new antitussive agents. We have investigated the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses in rabbits and guinea pigs. Ozone induced a significant increase
Chengwen Mao et al.
AAPS PharmSciTech, 10(3), 1058-1064 (2009-08-12)
In this study, a nanoemulsion (NE) system was investigated for intravenous delivery of lipophilic and venous irritant drugs. NEs were prepared to deliver diallyl trisulfide (DT) for systemic therapy of bacterial and fungal infection, egg phospholipid was chosen as the
Arnaud Vonarbourg et al.
Biomaterials, 30(18), 3197-3204 (2009-03-31)
Most of DNA synthetic complexes result from the self-assembly of DNA molecules with cationic lipids or polymers in an aqueous controlled medium. However, injection of such self-assembled complexes in medium like blood that differ from that of their formulation leads

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.