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Merck

71725

Sodium dodecyl sulfate

greener alternative

BioUltra, Molecular Biology, ≥99.0% (GC)

동의어(들):

Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt, SDS, Sodium lauryl sulfate

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
CH3(CH2)11OSO3Na
CAS 번호:
151-21-3
Molecular Weight:
288.38
NACRES:
NA.25
PubChem Substance ID:
57652353
eCl@ss:
39093306
UNSPSC Code:
12161900
EC Number:
205-788-1
MDL number:
MFCD00036175
Beilstein/REAXYS Number:
3599286

주요 문서

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제품 이름

Sodium dodecyl sulfate, BioUltra, Molecular Biology, ≥99.0% (GC)

InChI key

DBMJMQXJHONAFJ-UHFFFAOYSA-M

InChI

1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

SMILES string

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

grade

Molecular Biology

description

anionic

product line

BioUltra

assay

≥99.0% (GC)

form

powder

mol wt

micellar avg mol wt 18,000

Quality Level

200

greener alternative product characteristics

Catalysis
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

aggregation number

62

impurities

DNases, none detected
 RNases, none detected
 insoluble matter, passes filter test
 phosphatases, none detected
 proteases, none detected

loss

≤3% loss on drying, 20 °C (HV)

CMC

7-10 mM (20-25°C)

mp

204-207 °C (lit.)

transition temp

cloud point >100 °C

solubility

H2O: 0.1 M at 20 °C, clear, colorless

density

0.455 g/cm3

anion traces

chloride (Cl-): ≤200 mg/kg
phosphate (PO43-): ≤1 mg/kg

cation traces

Al: ≤5 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

0.1 M in H2O

UV absorption

λ: 260 nm Amax: 0.04
λ: 280 nm Amax: 0.02

HLB

40

suitability

suitable for electrophoresis

greener alternative category

Aligned

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관련 카테고리

Application

Anionic detergent
Sodium dodecyl sulfate has been used:
  • as an ionic surfactant in polystyrene (PS) particle suspension for surfactant-based experiments
  • in phosphate-buffered saline as a component of lysis buffer to homogenize myometrium and leiomyoma tissue
  • as a component of lysis buffer to dissolve formazans
  • as a component of high-salt nuclear extraction buffer

Biochem/physiol Actions

Sodium dodecyl sulfate (SDS) serves as an important detergent in the structural biology field and protein folding/unfolding studies. The sulfate groups and alkyl chains of SDS can strongly bind to the positively charged and the hydrophobic residues of proteins. SDS induces the formation of α-helices in a protein structure. At high concentrations, SDS stimulates cooperative unfolding in various proteins such as bovine serum albumin (BSA), hen egg-white lysozyme, -lactalbumin, and -lactoglobulin structures.

Features and Benefits

  • Suitable for molecular biology and biochemical research
  • BioUltra grade for your sensitive applications
  • Free from DNase, RNase, NICKase and protease
  • Tested for trace levels of Anions and Cations
  • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications

  • Undergoes hydrolysis at high temperatures, especially in acidic medium

General description

Sodium dodecyl sulfate (SDS), also known as sodium lauryl sulfate, is a versatile anionic surfactant with a broad range of applications in molecular biology, biochemistry, and various industries. Its amphiphilic nature, characterized by a hydrophobic hydrocarbon tail and a hydrophilic sulfate head group, makes it an effective detergent capable of solubilizing and denaturing proteins, lipids, and other hydrophobic molecules.

In protein biochemistry, SDS plays a pivotal role in protein extraction and SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis). Its ability to denature proteins by disrupting their secondary and tertiary structures allows for their uniform migration during gel electrophoresis, enabling the separation and analysis of proteins based on their molecular weight. This technique has become an indispensable tool for identifying and characterizing proteins in biological samples.

Beyond its role in protein analysis, SDS also finds utility in nucleic acid extraction and various hybridization techniques. Its detergent properties aid in the lysis of cells and the release of nucleic acids, facilitating their subsequent purification and analysis. Additionally, SDS is employed in hybridization techniques to promote the annealing of complementary nucleic acid strands, enabling the detection and analysis of specific DNA or RNA sequences.
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Other Notes

For additional information on our range of Biochemicals, please complete this form.

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Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Flam. Sol. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

저장 등급

4.1B - Flammable solid hazardous materials

wgk

WGK 2

flash_point_f

338.0 °F

flash_point_c

170 °C

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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시험 성적서(COA)

Lot/Batch Number
SDBB5680
SDBB4983
SDBB3953
SDBB3697
SDBB3187

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