72340
Nicotinamide
≥99.5% (HPLC)
동의어(들):
Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C6H6N2O
CAS 번호:
Molecular Weight:
122.12
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
EC Number:
202-713-4
Beilstein/REAXYS Number:
383619
MDL number:
biological source
synthetic
Quality Level
assay
≥99.5% (HPLC)
form
powder or crystals
ign. residue
≤0.2%
loss
≤0.2% loss on drying, 20 °C (HV)
color
colorless to white
mp
128-131 °C
anion traces
chloride (Cl-): ≤50 mg/kg, sulfate (SO42-): ≤150 mg/kg
cation traces
Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg
application(s)
cell analysis
SMILES string
NC(=O)c1cccnc1
InChI
1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChI key
DFPAKSUCGFBDDF-UHFFFAOYSA-N
Gene Information
human ... PARP1(142), SIRT2(22933)
General description
Nicotinamide, a form of vitamin B3, is a building block of coenzymes NAD and NADP. Researchers consider it an important signaling molecule, and essential for cell metabolism studies. It has been used in multiple applications and research areas, namely cancer and viral research.
Application
Nicotinamide has been used:
- to study its effect on the expression of sirtuin 1
- in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay
- in cell lysis buffer, to serve as a sirtuin 1 inhibitor in order to study its role in resveratrol (RSV)-stimulated hepatitis B virus replication
Biochem/physiol Actions
The coenzymes NAD and NADP take part in energy yielding metabolism and mediate several oxidation-reduction reactions. NAD hydrolyses to form nicotinamide, which is then transported to other tissues. Hydrolysis of nicotinamide yields nicotinic acid through salvage pathway.
Nicotinamide (Niacinamide) (Nam) is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). Nicotinamide may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule.
Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
Other Notes
Coenzymes and Cofactors, vol. 2: Pyridine Nucleotide Coenzymes
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
302.0 °F - closed cup
flash_point_c
150 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Chemical, Biochemical and Medical Aspects, 776-776 null
Human Nutrition, 206-206 (2010)
D.Dolphin, R.Poulson, O.Avramovic, eds.
Chemical, Biochemical and Medical Aspects, 759-759 (1987)