73677
4-Nitrophenyl β-D-glucuronide
β-glucuronidase substrate, chromogenic, ≥99.0% (TLC), powder or crystals, suitable as substrate for β-glucuronidase test
동의어(들):
4-Nitrophenyl-β-D-glucopyranosiduronic acid, PNPG
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H13NO9
CAS 번호:
Molecular Weight:
315.23
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
233-753-0
MDL number:
Beilstein/REAXYS Number:
1438576
제품 이름
4-Nitrophenyl β-D-glucuronide, ≥99.0% (TLC)
InChI key
QSUILVWOWLUOEU-GOVZDWNOSA-N
InChI
1S/C12H13NO9/c14-7-8(15)10(11(17)18)22-12(9(7)16)21-6-3-1-5(2-4-6)13(19)20/h1-4,7-10,12,14-16H,(H,17,18)/t7-,8-,9+,10-,12+/m0/s1
SMILES string
O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H]1O)C(O)=O)Oc2ccc(cc2)[N+]([O-])=O
assay
≥99.0% (TLC)
form
powder or crystals
optical activity
[α]20/D −102±3°, c = 1% in ethanol
impurities
≤0.05% free 4-nitrophenol, ≤7% water
solubility
H2O: 0.1 g/mL, clear, faintly yellow
suitability
suitable as substrate for β-glucuronidase test
storage temp.
−20°C
Quality Level
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General description
Chromogenic substrate for β-glucuronidase (GUS) gene detection.
Application
4-Nitrophenyl β-D-glucuronide has been used for determining the β-glucuronidase activity in urine samples, β-glucuronidase activity of bacteria in caecum content digesta and bovine liver. It has also been used to study the inhibitory effect of Phyllanthus amarus extracts on β-glucuronidase.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice
El-Arab AME, et al.
BMC Complementary and Alternative Medicine, 6(1), 6-6 (2006)
Effect of tobacco smoking on albumin concentration and beta-glucuronidase activity in urine of smelters
Bizonn A, et al.
Przegla?d Lekarski, 71(11), 581-584 (2014)
Synthesis of Glycaro-1, 5-lactams and Tetrahydrotetrazolopyridine-5-carboxylates: Inhibitors of beta-D-Glucuronidase and alpha-L-Iduronidase
Pabba J, et al.
Helvetica Chimica Acta, 89(4), 635-666 (2006)
E E Guibert et al.
Experientia, 39(5), 527-528 (1983-05-15)
The effect of spironolactone (SP) on p-nitrophenol (PNP) glucuronidation was studied in isolated rat hepatocytes with appropriate viability conditions. A significant increase of protein concentration and PNP glucuronidation was found in the hepatocytes from SP-treated rats. Increased enzyme activity apparently
C Y Ng et al.
The Journal of pharmacology and experimental therapeutics, 295(2), 830-835 (2000-10-25)
Congestive heart failure has been shown to affect oxidative drug metabolism, however, there has been little study of its effects on drug conjugation. Using the isolated perfused livers from rats with right ventricular failure (RVF) due to pulmonary artery constriction
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