85610
Spermine tetrahydrochloride
From microbial,synthetic, ≥99.0% (AT), NMDA agonist/antagonist, powder or crystals
동의어(들):
N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H26N4 · 4HCl
CAS 번호:
Molecular Weight:
348.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-189-8
MDL number:
Beilstein/REAXYS Number:
3911771
제품 이름
Spermine tetrahydrochloride, ≥99.0% (AT), powder or crystals
SMILES string
Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
InChI key
XLDKUDAXZWHPFH-UHFFFAOYSA-N
InChI
1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
biological source
microbial, synthetic
assay
≥99.0% (AT)
form
powder or crystals
mp
310-311 °C (dec.) (lit.)
solubility
H2O: 0.1 g/mL, clear
storage temp.
room temp
Quality Level
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Application
Used to precipitate DNA from low salt aqueous buffers.
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Anna Czajkowska-Mysłek et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 105, 82-92 (2017-04-04)
Potential adverse reactions among infants and young children could appear after consumption of food containing small amounts of bioactive amines. This study presents the first assessment of biogenic amines occurrence in ready-to-eat vegetable without/with fish, meat and fruit baby products
Desiree Bailey et al.
Pharmacology, biochemistry, and behavior, 133, 57-64 (2015-04-01)
The aim of this study was to examine the acute effect of a range of novel hydroxycinnamic acid derivatives of spermine on the development of spermine-induced CNS excitation and convulsions in female Laca mice, and to assess the chronic adverse
Yong Kee Choi et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(2), 77-84 (2008-10-11)
Levels of ionotropic glutamate (Glu) N-methyl-d-aspartic acid (NMDA), 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA), and kainic acid (KA) receptors in forebrain regions of juvenile rats (age 42 days) were quantified after 3 weeks of treatment with three different doses of risperidone (0.3, 1.0
Enzo Agostinelli et al.
International journal of oncology, 45(3), 1109-1122 (2014-06-28)
It has been confirmed that multidrug resistant (MDR) melanoma cells (M14 ADR2) are more sensitive than their wild-type counterparts (M14 WT) to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine. The metabolites formed by
Alexis Goichon et al.
The American journal of clinical nutrition, 102(2), 359-367 (2015-06-26)
Amino acids are well known to be key effectors of gut protein turnover. We recently reported that enteral delivery of proteins markedly stimulated global duodenal protein synthesis in carbohydrate-fed healthy humans, but specifically affected proteins remain unknown. We aimed to
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