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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
GB-69, monoclonal
Application:
DB, ELISA (i), IF, IHC
Citations:
75
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
GB-69, monoclonal
contains
15 mM sodium azide
species reactivity
wide range
technique(s)
dot blot: suitable, immunofluorescence: suitable, immunohistochemistry: 1:100-1:200 (Using heat-retrieved formalin-fixed, paraffin-embedded human brain and/or cerebellum sections.), indirect ELISA: suitable
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Gabra1(14394)
General description
γ-Aminobutyric acid (GABA) functions as an inhibitory neurotransmitter in the central nervous system. It also functions as a neuromodulator in some peripheral tissues. Additionally, GABA is present in non-nervous tissues and regulates blood pressure, heart rate, respiration, immunomodulation, cell proliferation, protein synthesis and metabolism.
Monoclonal Anti-GABA (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The antibody does not cross react with L-α-aminobutyric acid, L-glutamic acid, L-aspartic acid, glycine, δ-aminovaleric acid, L-threonine, L-glutamine, taurine, putrescine, L-alanine and carnosine. However, weak cross-reaction is observed with β-alanine and ε-aminocaproic acid.
Monoclonal Anti-GABA (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The antibody does not cross react with L-α-aminobutyric acid, L-glutamic acid, L-aspartic acid, glycine, δ-aminovaleric acid, L-threonine, L-glutamine, taurine, putrescine, L-alanine and carnosine. However, weak cross-reaction is observed with β-alanine and ε-aminocaproic acid.
Monoclonal Anti-GABA (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and a neuromodulator in certain peripheral tissues. GABA is also present in non-nervous structures.
Immunogen
GABA (γ-aminobutyric acid) conjugated to BSA
Application
Monoclonal Anti-GABA antibody produced in mouse has been used in immunohistochemistry and immunocytochemistry.
Biochem/physiol Actions
γ-Aminobutyric acid (GABA) mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Physical form
Supplied as ascites fluid with 15 mM sodium azide as preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Structure, function, and modulation of GABAA receptors
Sigel E and Steinmann ME
The Journal of Biological Chemistry, 287(48), 40224-40231 (2012)
Newborn horizontal cells migrate bi-directionally across the neuroepithelium during retinal development
Edqvist PHD and Hallbook F
Development, 131(6), 1343-1351 (2004)
Per-Henrik D Edqvist et al.
Development (Cambridge, England), 131(6), 1343-1351 (2004-02-20)
Cell migration plays an important role during the development of the retina. In this work we have studied the migration of newborn horizontal cells in avian embryonic retina. Using the pattern of the early expressed transcription factors Lim1 and Prox1
GABA may be a neurotransmitter in the vertebrate peripheral nervous system
Jessen KR, et al.
Nature, 281(5726), 71-71 (1979)
Christine J Huh et al.
eLife, 5 (2016-10-18)
Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The ability to recapitulate age-related characteristics of human neurons in culture will offer unprecedented opportunities to study the biological processes underlying neuronal aging. Here, we show that
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