A1260
Amantadine hydrochloride
≥98% (TLC), powder, NMDA receptor antagonist
동의어(들):
1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, NSC 83653, Tricyclo[3.3.1.13,7]decan-1-amine hydrochloride
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H17N · HCl
CAS 번호:
Molecular Weight:
187.71
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
211-560-2
MDL number:
Beilstein/REAXYS Number:
4198854
제품 이름
Amantadine hydrochloride,
InChI
1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI key
WOLHOYHSEKDWQH-SOVZANNPSA-N
SMILES string
Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
form
powder
solubility
H2O: 50 mg/mL
ethanol: soluble
originator
Endo
Quality Level
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관련 카테고리
Application
Amantadine hydrochloride has been used:
- to determine its effectiveness in reducing surgery-induced cognitive impairment
- to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway
- to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory
- to preincubate primary cultured rat dental pulp stem cells (rDPSCs)
- to determine the pathway of internalization
Biochem/physiol Actions
Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.
Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Intracellular co-delivery of Sr ion and phenamil drug through mesoporous bioglass nanocarriers synergizes BMP signaling and tissue mineralization
Lee J H, et al.
Acta Biomaterialia, 93-108 (2017)
Amantadine attenuates sepsis-induced cognitive dysfunction possibly not through inhibiting toll-like receptor 2
Xing W, et al.
Journal of Molecular Medicine, 96(5), 391-402 (2018)
John Whyte et al.
Archives of physical medicine and rehabilitation, 94(10), 1877-1883 (2013-06-06)
To assess the incidence of medical complications in patients with recent traumatic disorders of consciousness (DOCs). Data on adverse events in a placebo controlled trial of amantadine hydrochloride revealed no group difference, which allowed these events to be reanalyzed descriptively
Amantadine ameliorates dopamine-releasing deficits and behavioral deficits in rats after fluid percussion injury
Huang E Y K, et al.
Testing, 9(1), e86354-e86354 (2014)
Effect of aminated mesoporous bioactive glass nanoparticles on the differentiation of dental pulp stem cells
Lee J H, et al.
Testing, 11(3), e0150727-e0150727 (2016)
문서
Discover Bioactive Small Molecules for ADME/Tox
관련 콘텐츠
ADME/Tox를 위한 생체 활성 저분자
Product Information Sheet
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