A1895
Aurintricarboxylic acid
≥85% purity (titration), practical grade, powder
동의어(들):
ATA
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C22H14O9
CAS 번호:
Molecular Weight:
422.34
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
224-628-1
MDL number:
제품 이름
Aurintricarboxylic acid, practical grade, ≥85% (titration), powder
Quality Level
InChI key
GIXWDMTZECRIJT-UHFFFAOYSA-N
InChI
1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
SMILES string
OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O
grade
practical grade
assay
≥85% (titration)
form
powder
technique(s)
titration: suitable
color
red to very dark red, and Red-Brown andBrown-Red
mp
300 °C (lit.)
solubility
1 M NH4OH: 10 mg/mL
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
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Application
- Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum.
- It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase).
- It has been used as a ribonuclease inhibitor.
Biochem/physiol Actions
Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease that is activated during apoptosis.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
In vitro and in vivo activity of aurintricarboxylic acid preparations against Cryptosporidium parvum.
Klein P, et al.
The Journal of Antimicrobial Chemotherapy, 62, 1101-1104 (2008)
Red Light-Independent Instability of Oat Phytochrome mRNA in Vivo.
Seeley KA, et al.
Plant Cell, 4, 29-38 (1992)
Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase.
Sun Y, et al.
Antiviral Research, 104, 156-164 (2014)
Fumihito Noguchi et al.
Molecular cancer therapeutics, 16(5), 936-947 (2017-02-23)
Extracellular acidity is a hallmark of cancers and is independent of hypoxia. Because acidity potentiates malignant phenotypes, therapeutic strategies that enhance the targeting of oncogenic mechanisms in an acidic microenvironment should be effective. We report here that drugs which abrogate
Giuseppe Manfroni et al.
Bioorganic & medicinal chemistry, 20(2), 866-876 (2011-12-27)
Hepatitis C virus (HCV) infection has been recognized as the major cause of liver failure that can lead to hepatocellular carcinoma. Among all the HCV proteins, NS5B polymerase represents a leading target for drug discovery strategies. Herein, we describe our
관련 콘텐츠
Product Information Sheet
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