A2251
Acetyl-β-methylcholine chloride
≥98% (TLC), powder
동의어(들):
(2-Acetoxypropyl)trimethylammonium chloride, Methacholine chloride
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
CH3COOCH(CH3)CH2N(Cl)(CH3)3
CAS 번호:
Molecular Weight:
195.69
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-537-2
Beilstein/REAXYS Number:
4162373
MDL number:
Assay:
≥98% (TLC)
InChI
1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1
InChI key
JHPHVAVFUYTVCL-UHFFFAOYSA-M
SMILES string
[Cl-].CC(C[N+](C)(C)C)OC(C)=O
assay
≥98% (TLC)
form
powder
mp
171-173 °C (lit.)
solubility
H2O: 50 mg/mL (solutions undergo rapid, pH-dependent decomposition at pH > 6.)
storage temp.
−20°C
Quality Level
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
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Application
Acetyl-β-methylcholine (methacholine), an analog of acetylcholine, is use as a receptor agonist to study processes such as airway hyperresponsiveness associated with asthma.
Biochem/physiol Actions
Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Bing Han et al.
PloS one, 6(2), e17236-e17236 (2011-03-02)
The great advances of nanomaterials have brought out broad important applications, but their possible nanotoxicity and risks have not been fully understood. It is confirmed that exposure of environmental particulate matter (PM), especially ultrafine PM, are responsible for many lung
J G Martin et al.
Canadian journal of physiology and pharmacology, 70(4), 597-601 (1992-04-01)
Airway responsiveness to methacholine and other bronchoconstrictors is highly variable within and among species. The aim of the experiments in this report was to evaluate the importance of the quantity of airway smooth muscle as a determinant of intra- and
Mina Youssef et al.
The Journal of pharmacology and experimental therapeutics, 373(3), 476-487 (2020-04-11)
Zona pellucida binding protein 2 (Zpbp2) and ORMDL sphingolipid biosynthesis regulator 3 (Ormdl3), mapped downstream of Zpbp2, were identified as two genes associated with airway hyper-responsiveness (AHR). Ormdl3 gene product has been shown to regulate the biosynthesis of ceramides. Allergic
Martijn C Nawijn et al.
PloS one, 8(2), e55307-e55307 (2013-02-09)
Asthma is a chronic inflammatory disease of the airways characterized by variable airway obstruction and airway hyperresponsiveness (AHR). The T regulatory (Treg) cell subset is critically important for the regulation of immune responses. Adoptive transfer of Treg cells has been
Roy H E Cloots et al.
American journal of physiology. Lung cellular and molecular physiology, 305(5), L364-L376 (2013-07-09)
Asthma is a chronic inflammatory disease of the small airways, with airway hyperresponsiveness (AHR) and inflammation as hallmarks. Recent studies suggest a role for arginase in asthma pathogenesis, possibly because arginine is the substrate for both arginase and NO synthase
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