A2942

Amphotericin B

Name: Amphotericin B
Brand: SIGMA

solution, suitable for cell culture, BioReagent

동의어(들):

Amphotericin, Fungizone

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₄₇H₇₃NO₁₇

CAS 번호:

1397-89-3

Molecular Weight:

924.08

UNSPSC Code:

12352207

PubChem Substance ID:

24890711

NACRES:

NA.76

MDL number:

MFCD00877763

주요 문서

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제품 이름

Amphotericin B solution, 250 μg/mL in deionized water, 0.1 μm filtered, BioReagent, suitable for cell culture

SMILES string

[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(=O)O[Na])O2

InChI

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

APKFDSVGJQXUKY-INPOYWNPSA-N

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

concentration

250 μg/mL in deionized water

technique(s)

cell culture | mammalian: suitable

color

yellow

antibiotic activity spectrum

fungi
yeast

mode of action

cell membrane | interferes

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

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Application

Amphotericin B solution has been used:

as an intraperitoneal injection for the treatment of Aspergillus fumigatus infection in mice
as a constituent of aspiration medium for the culture of Chinese Merino ewe ovaries
as a constituent of transport medium during the collection of equine corpora lutea
as a supplement in RPMI medium for the culture of the mouse-mouse B cell hybridoma 55-6 cell line

Biochem/physiol Actions

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. that is clinically used to treat systemic fungal infections. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.

Amphotericin B is most effective against fungi and yeast. It forms transmembrane channels by binding to sterols associated with membranes, thereby leading to the leakage of small molecules. Amphotericin B elicits toxicity despite being an effective antibiotic for treating mycoses.

Disclaimer

Amphotericin B remains active for 3 days in culture at 37°C.

General description

Amphotericin B is a macrocyclic lactone with a hydrophilic polyhydroxyl chain and a lipophilic polyene based hydrocarbon chain.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

This product is supplied as 250 μg/mL Amphotericin B in deionized water. It is a solution containing Amphotericin B, and the following components aimed to improve its solubility: sodium deoxycholate, sodium chloride and sodium phosphate.

Packaging

20,50,100ml

Preparation Note

It is not unusual for this material to form a precipitate in aqueous solutions. Mixing the solution will redissolve most of the precipitate but, if it does not fully resolubilize, the Amphotericin B will still be suitable for use.

저장 등급

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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문서 라이브러리 방문

Analysis of kinetic, stoichiometry and regulation of glucose and glutamine metabolism in hybridoma batch cultures using logistic equations.

María Lourdes Acosta et al.

Cytotechnology, 54(3), 189-200 (2008-11-13)

Batch cultures were carried out to study the kinetic, stoichiometry, and regulation of glucose and glutamine metabolism of a murine hybridoma line. Asymmetric logistic equations (ALEs) were used to fit total and viable cell density, and nutrient and metabolite/product concentrations.

A newly identified derivative of amphotericin B: isolation, structure determination and primary evaluation of the activity and toxicity.

Yong-Hong Wang et al.

The Journal of antibiotics, 63(9), 553-557 (2010-07-08)

A new derivative of amphotericin B named amphotericin B(5) has been obtained under the following condition: amphotericin B powder was first dissolved in N,N-dimethylformamide at room temperature to obtain a solution of concentration of 2.0 mg ml(-1). Then, the solution

Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling.

Luigina Romani et al.

Blood, 103(11), 4232-4239 (2004-02-26)

Dendritic cells (DCs) show a remarkable functional plasticity in the recognition of Aspergillus fumigatus and orchestrate the antifungal immune resistance in the lungs. Here, we show that thymosin alpha 1, a naturally occurring thymic peptide, induces functional maturation and interleukin-12

One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium.

J Bolard et al.

Biochemistry, 30(23), 5707-5715 (1991-06-11)

The inducement of K+ permeability through membranes by the polyene antibiotic amphotericin B (AmB) has been analyzed as a measure of the antibiotic activity. Dose-response curves have been obtained with cholesterol- and ergosterol-containing egg yolk phosphatidylcholine large unilamellar vesicles (LUVs)

Modes of the antibiotic activity of amphotericin B against Candida albicans.

Ewa Grela et al.

Scientific reports, 9(1), 17029-17029 (2019-11-21)

Amphotericin B is an antibiotic used as the "gold standard" in the treatment of life-threatening fungal infections. Several molecular mechanisms have been proposed to explain exceptionally high effectiveness of amphotericin B in combating fungi. In the present work, we apply

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Amphotericin B

solution, suitable for cell culture, BioReagent

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI

InChI key

sterility

product line

form

concentration

technique(s)

color

antibiotic activity spectrum

mode of action

shipped in

storage temp.

Quality Level

관련 카테고리

설명

Application

Biochem/physiol Actions

Disclaimer

General description

Other Notes

Packaging

Preparation Note

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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