A4352
Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
๋์์ด(๋ค):
Anti-phospho-AMPA Glutamate Receptor 1 (pSer831)
์กฐ์ง ๋ฐ ๊ณ์ฝ ๊ฐ๊ฒฉ์ ๋ณด๋ ค๋ฉด ๋ก๊ทธ์ธ๋ฅผ ํด๋ฆญํฉ๋๋ค.
ํฌ๊ธฐ ์ ํ
์ ํ์ ๋ณด (DICE ๋ฐฐ์ก ์ ๋น์ฉ ๋ณ๋)
Conjugate:
unconjugated
Clone:
polyclonal
Application:
direct ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Species reactivity:
rat, human
Citations:
7
Technique(s):
direct ELISA: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1:1,000 using rat brain (hippocampal) homogenate
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1:1,000 using rat brain (hippocampal) homogenate
Uniprot accession no.:
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Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 100 kDa
species reactivity
rat, human
concentration
~1 mg/mL
technique(s)
direct ELISA: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1:1,000 using rat brain (hippocampal) homogenate
UniProt accession no.
shipped in
dry ice
storage temp.
−20ยฐC
target post-translational modification
phosphorylation (pSer831)
Quality Level
Gene Information
human ... GRIA1(2890)
rat ... Gria1(50592)
Application
Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody is suitable for use in direct ELISA, immunohistochemistry, immunoblot and immunoprecipitation. The antibody may also be used for western blot (1:1,000 using rat hippocampal homogenate).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
AMPA is a transmembrane receptor for glutamate that regulates synapsis in the central nervous system. It is composed of 4 types of subunits, GluR1, 2, 3, 4.
GluR1 subunits of AMPA receptors are membrane proteins that regulate synaptic plasticity of the central nervous system. This receptor has also been implicated in spatial memory retention. Phosphorylation of serine 831 in GluR1 subunit of the AMPA receptor modulates long-term potentiation in neuronal synapses. Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody is specific for the GluR1 subunit (phosphorylated on serine 831) of the AMPA receptor in rats and humans.
Immunogen
The GluR1 sequence is conserved among species and has partial homology to VGLUT2.
synthetic phosphopeptide corresponding to a region near serine 831 of rat glutamate receptor subunit GluR1.
Physical form
Solution in 10 mM HEPES buffer, pH 7.5, containing 150 mM NaCl, 100 ฮผg/ml BSA and 50% glycerol.
์ ํฉํ ์ ํ์ ์ฐพ์ ์ ์์ผ์ ๊ฐ์? ย
๋น์ฌ์ ์ ํ ์ ํ๊ธฐ ๋๊ตฌ.์(๋ฅผ) ์๋ํด ๋ณด์ธ์.
์ ์ฅ ๋ฑ๊ธ
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
๊ฐ์ฅ ์ต์ ๋ฒ์ ์ค ํ๋๋ฅผ ์ ํํ์ธ์:
์ด ์ ํ์ ์ด๋ฏธ ๊ฐ์ง๊ณ ๊ณ์ญ๋๊น?
๋ฌธ์ ๋ผ์ด๋ธ๋ฌ๋ฆฌ์์ ์ต๊ทผ์ ๊ตฌ๋งคํ ์ ํ์ ๋ํ ๋ฌธ์๋ฅผ ์ฐพ์๋ณด์ธ์.
Rodrigo Bainy Leal et al.
Molecular psychiatry, 25(3), 655-665 (2018-06-09)
Fear is a conscious state caused by exposure to real or imagined threats that trigger stress responses that affect the body and brain, particularly limbic structures. A sub-group of patients with mesial temporal lobe epilepsy related to hippocampus sclerosis (MTLE-HS)
Hey-Kyoung Lee et al.
Cell, 112(5), 631-643 (2003-03-12)
Plasticity of the nervous system is dependent on mechanisms that regulate the strength of synaptic transmission. Excitatory synapses in the brain undergo long-term potentiation (LTP) and long-term depression (LTD), cellular models of learning and memory. Protein phosphorylation is required for
Hey-Kyoung Lee et al.
Journal of neurophysiology, 103(1), 479-489 (2009-11-13)
Activity-dependent changes in excitatory synaptic transmission in the CNS have been shown to depend on the regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). In particular, several lines of evidence suggest that reversible phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1
Promotion of bone cancer pain development by decorin is accompanied by modification of excitatory synaptic molecules in the spinal cord.
Huan Wang et al.
Molecular pain, 15, 1744806919864253-1744806919864253 (2019-07-02)
Xiang Cai et al.
Nature neuroscience, 16(4), 464-472 (2013-03-19)
The causes of major depression remain unknown. Antidepressants elevate concentrations of monoamines, particularly serotonin, but it remains uncertain which downstream events are critical to their therapeutic effects. We found that endogenous serotonin selectively potentiated excitatory synapses formed by the temporoammonic
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Datasheet
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