A5282
DL-2-Amino-5-phosphonopentanoic acid
≥98% (TLC), solid, NMDA receptor antagonist
동의어(들):
5-Phosphono-DL-norvaline, DL-2-Amino-5-phosphonovaleric acid, AP-5, APV
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C5H12NO5P
CAS 번호:
Molecular Weight:
197.13
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
2446389
제품 이름
DL-2-Amino-5-phosphonopentanoic acid, solid
form
solid
color
white
InChI
1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
SMILES string
NC(CCCP(O)(O)=O)C(O)=O
InChI key
VOROEQBFPPIACJ-UHFFFAOYSA-N
solubility
0.1 M NaOH: 4 mg/mL
H2O: 5.6 mg/mL
organic solvents: insoluble
Quality Level
Gene Information
rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)
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관련 카테고리
Application
DL-2-Amino-5-phosphonopentanoic acid has been used:
- in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
- used in growth medium for inhibition of electrical activity in the neuronal network
- used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
- used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)
Biochem/physiol Actions
Anticonvulsant; potent and selective NMDA receptor antagonist.
Disclaimer
Hygroscopic
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation
Weitlauf C, et al.
The Journal of Neuroscience, 25(37), 8386-8390 (2005)
Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode arrays
Shein M, et al.
Biomedical Microdevices, 11(2), 495-501 (2009)
Ryota Kobayashi et al.
Frontiers in computational neuroscience, 3, 9-9 (2009-08-12)
Information is transmitted in the brain through various kinds of neurons that respond differently to the same signal. Full characteristics including cognitive functions of the brain should ultimately be comprehended by building simulators capable of precisely mirroring spike responses of
Marijn van Wingerden et al.
Neuron, 76(4), 813-825 (2012-11-28)
Neural activity in orbitofrontal cortex has been linked to flexible representations of stimulus-outcome associations. Such value representations are known to emerge with learning, but the neural mechanisms supporting this phenomenon are not well understood. Here, we provide evidence for a
Bence P Olveczky et al.
PLoS biology, 3(5), e153-e153 (2005-04-14)
Songbirds learn their songs by trial-and-error experimentation, producing highly variable vocal output as juveniles. By comparing their own sounds to the song of a tutor, young songbirds gradually converge to a stable song that can be a remarkably good copy
관련 콘텐츠
Product Information Sheet
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