A6185

Calpain Inhibitor I

Name: Calpain Inhibitor I
Brand: SIGMA

synthetic (organic), ≥97% (TLC), cysteine protease inhibitor, powder

동의어(들):

ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Norleu-al

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₀H₃₇N₃O₄

CAS 번호:

110044-82-1

Molecular Weight:

383.53

NACRES:

NA.77

PubChem Substance ID:

24891066

UNSPSC Code:

12352200

MDL number:

MFCD00065505

Beilstein/REAXYS Number:

7656053

Assay:

≥97% (TLC)

Form:

powder

Quality level:

200

주요 문서

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제품 이름

Calpain Inhibitor I, ≥97% (TLC), powder

biological source

synthetic (organic)

Quality Level

200

assay

≥97% (TLC)

form

powder

color

white

solubility

DMSO: soluble, ethanol: soluble

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

InChI

1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1

InChI key

FMYKJLXRRQTBOR-BZSNNMDCSA-N

Gene Information

human ... CAPN1(823), CTSB(1508), PSMA1(5682)

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Application

Calpain Inhibitor I have been used:

as a component of protease inhibitor cocktail for gel shift analysis
for treating HeLa cell cultures
for inhibition of 26 S proteasome in 26 S proteasome inhibition assays

Biochem/physiol Actions

Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G₁/S and at meta-/anaphase. Blocks induction of nitric oxide synthase by LPS in macrophages.

Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis. It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL..

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein

Cheong J K, et al.

The Journal of Biological Chemistry, 283(17), 11661-11676 (2008)

Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression

Benkhart E M, et al.

Journal of Immunology, 165(3), 1612-1617 (2000)

The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles

Mayor T, et al.

Journal of Cell Science, 115(16), 3275-3284 (2002)

Cleavage of the calpain inhibitor, calpastatin, during apoptosis

Porn-Ares M I, et al.

Cell Death and Differentiation, 5(12), 1028-1028 (1998)

Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.

J M Griscavage et al.

Proceedings of the National Academy of Sciences of the United States of America, 93(8), 3308-3312 (1996-04-16)

The objective of this study was to elucidate the role of the proteasome pathway or multicatalytic proteinase complex in the induction of immunologic nitric oxide (NO) synthase (iNOS) in rat alveolar macrophages activated by lipopolysaccharide. Macrophages were incubated in the

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문서

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Calpain Inhibitor I

synthetic (organic), ≥97% (TLC), cysteine protease inhibitor, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

biological source

Quality Level

assay

form

color

solubility

storage temp.

SMILES string

InChI

InChI key

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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