A7481
Anti-Atg1/ULK1 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
동의어(들):
Anti-UNC51, Anti-Unc-51 like kinase 1 (C. elegans), Anti-Unc51.1
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
100
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~150 kDa
species reactivity
rat, human (predicted), mouse
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1 mg/mL
technique(s)
western blot: 0.5-1.0 μg/mL using whole extracts of HEK-293T cells expressing mouse ULK1, western blot: 3-6 μg/mL using whole extracts of rat PC12
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ULK1(8408)
mouse ... Ulk1(22241)
rat ... Ulk1(360827)
General description
Atg1 is an autophagy protein that functions as a serine/threonine kinase in yeast to regulate autophagasome formation. Atg1 is ULK1 in mammals.
Unc-51 like autophagy activating kinase 1 (ULK1) gene is located on human chromosome 12q24.33.
Immunogen
Synthetic peptide corresponding to amino acids of mouse Atg1/ULK1 conjugated to KLH via a cysteine residue. The corresponding sequence is identical in rat and differs by 3 amino acids in human.
Application
Anti-Atg1/ULK1 antibody produced in rabbit has been used in western blotting and immunohistochemical staining.
Biochem/physiol Actions
Anti- Atg1/ULK1 recognizes rat and mouse Atg1/ULK1.
Unc-51 like autophagy activating kinase 1 (ULK1) regulates autophagy initiation and innate immunity of interferons (IFNs). ULK1 is critical for neuronal development. It is essential for neurite elongation and differentiation of cerebellar granule neurons. Mutations in this gene is linked to latent mycobacterium tuberculosis infection (LTBI).
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Beyond autophagy: New roles for ULK1 in immune signaling and interferon responses
Saleiro D, et al.
Cytokine & Growth Factor Reviews, 29, 17-22 (2016)
Noboru Mizushima et al.
Nature cell biology, 12(9), 823-830 (2010-09-03)
It has been known for many decades that autophagy, a conserved lysosomal degradation pathway, is highly active during differentiation and development. However, until the discovery of the autophagy-related (ATG) genes in the 1990s, the functional significance of this activity was
Human ULK1 variation and susceptibility to Mycobacterium tuberculosis infection
Horne DJ, et al.
The Journal of Infectious Diseases, 214(8), 1260-1267 (2016)
Gene responsible for mitochondrial myopathy and sideroblastic anemia (MSA) maps to chromosome 12q24. 33
Casas K, et al.
American Journal of Medical Genetics. Part A, 127(1), 44-49 (2004)
Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice
Tam BT, et al.
Pflugers Archiv : European Journal of Physiology, 467(12), 2555-2569 (2015)
관련 콘텐츠
Instructions
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