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Merck

A8231

AGK2

≥97% (HPLC), powder

동의어(들):

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C23H13Cl2N3O2
CAS 번호:
304896-28-4
Molecular Weight:
434.27
NACRES:
NA.77
PubChem Substance ID:
329770953
UNSPSC Code:
12352200
MDL number:
MFCD01909444
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100

주요 문서

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InChI key

SVENPFFEMUOOGK-SDNWHVSQSA-N

SMILES string

Clc1ccc(Cl)c(c1)-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4ncccc34)o2

InChI

1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+

assay

≥97% (HPLC)

form

powder

solubility

DMSO: 2 mg/mL, clear (warmed), H2O: insoluble

storage temp.

room temp

Quality Level

100

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관련 카테고리

Application

AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

Biochem/physiol Actions

AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.
AGK2 is a SIRT2 inhibitor; rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
0000164387
0000164388
0000164387
0000164388
0000133363

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리 방문

David T She et al.
Molecular neurobiology, 55(12), 9188-9203 (2018-04-15)
Sirtuin 2 (SIRT2) is a family member of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases which appears to have detrimental roles in an array of neurological disorders such as Parkinson's disease (PD) and Huntington's disease (HD). In light of the recently emerging
G L Garrote et al.
The Journal of dairy research, 68(4), 639-652 (2002-04-04)
Chemical and microbiological composition of four Argentinean kefir grains from different sources as well as characteristics of the corresponding fermented milk were studied. Kefir grains CIDCA AGK1, AGK2 and AGK4 did not show significant differences in their chemical and microbiological
Hai-Bo Yu et al.
International journal of medical sciences, 15(12), 1356-1364 (2018-10-03)
Sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD +)-dependent class III histone deacetylase. We have reported that HBx (hepatitis B virus X protein)-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis. However, the potential anti-HBV effect of AGK2, a selective inhibitor
Lisa M Giammona et al.
Experimental hematology, 37(11), 1340-1352 (2009-09-01)
Megakaryocytic cells (Mks) undergo endomitosis and become polyploid. Mk ploidy correlates with platelet production. We previously showed that nicotinamide (NIC) greatly increases Mk ploidy in cultures of human mobilized peripheral blood CD34(+) cells. This study aims to examine the generality
Hao Yang et al.
Experimental and therapeutic medicine, 20(2), 1415-1422 (2020-08-04)
Chemoresistance of colorectal cancer (CRC) leads to tumor recurrence and metastasis and new strategies are urgently needed to improve the outcomes of conventional chemotherapy. Sirtuin (SIRT) inhibitors prevent tumor cell growth by increasing the levels of acetylated histones and non-histones
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문서

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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