A9041
Arg-Gly-Asp-Ser
≥95% (HPLC)
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H27N7O8
CAS 번호:
Molecular Weight:
433.42
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Form:
powder
Assay:
≥95% (HPLC)
Biological source:
synthetic
InChI
1S/C15H27N7O8/c16-7(2-1-3-19-15(17)18)12(27)20-5-10(24)21-8(4-11(25)26)13(28)22-9(6-23)14(29)30/h7-9,23H,1-6,16H2,(H,20,27)(H,21,24)(H,22,28)(H,25,26)(H,29,30)(H4,17,18,19)/t7-,8-,9-/m0/s1
SMILES string
N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O
InChI key
NNRFRJQMBSBXGO-CIUDSAMLSA-N
biological source
synthetic
assay
≥95% (HPLC)
form
powder
composition
Peptide content, ~70%
technique(s)
cell culture | mammalian: suitable
storage temp.
−20°C
Quality Level
Gene Information
human ... ITGA2B(3674), ITGB3(3690)
mouse ... Itgb3(16416)
General description
The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.
RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor β1 (TGFβ1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated
to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages
RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor β1 (TGFβ1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated
to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages
Application
Arg-Gly-Asp-Ser has been used:
- to study its effects on cell attachment in rats
- to analyse the interaction of fibrinogen with erythrocytes occurs through integrin related receptor
- to pretreat the cells, to assess the role of integrin in the cell attachment process
- to test its competition with platelet-secreted, nanosheet-adsorbed proteins for binding to glycoprotein IIIa (GPIIIa)
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
This product is soluble in water (1 mg/ml), yielding a
clear, colorless solution.
clear, colorless solution.
Other Notes
Lyophilized from 0.1% TFA in H2O
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Toshiki Sawada et al.
Molecular bioSystems, 8(4), 1264-1274 (2012-02-02)
We obtained novel peptides that selectively bind to self-assembling peptide nanomaterials from a random peptide library displayed on phages. Affinity-dependent peptide screening gave phage clones displaying peptides with selective affinities against two kinds of highly networked nanofibers constructed of β-sheet
Lian Leng et al.
Advanced materials (Deerfield Beach, Fla.), 24(27), 3650-3658 (2012-06-21)
The one-step, continuous formation of mosaic hydrogel sheets is presented. A microfluidic device allows controllable incorporation of secondary biopolymers within a flowing biopolymer sheet followed by a cross-linking step that retains the microscale composition. Information is encoded; mosaic stiffness and
Valeria S Mouguelar et al.
Reproduction (Cambridge, England), 141(5), 581-593 (2011-02-23)
Integrins are cell adhesion molecules that are thought to be involved in sperm-oocyte interaction. Nevertheless, their function in mammalian fertilization is still controversial, as different species behave differently. In amphibians, their role is mainly supported by Xenopus laevis studies, where
Bartley J Gill et al.
Cancer research, 72(22), 6013-6023 (2012-09-07)
Better understanding of the biophysical and biochemical cues of the tumor extracellular matrix environment that influence metastasis may have important implications for new cancer therapeutics. Initial exploration into this question has used naturally derived protein matrices that suffer from variability
Gadolinium effects on gigaseal formation and the adhesive properties of a fungal amoeboid cell, the slime mutant of Neurospora crassa
Dunina BAY, et al.
The Journal of Membrane Biology, 198(2), 77-87 (2004)
문서
Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.
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