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Merck

A9525

Angiotensin II human

≥93% (HPLC), powder

동의어(들):

1-8-AngiotensinI, 5-Isoleucine-angiotensinII, Ang II, Angiotensin 2, Angiotensin II, DRVYIHPF, Hypertensin, Ile(5)-angiotensinII

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C50H71N13O12
CAS 번호:
4474-91-3
Molecular Weight:
1046.18
MDL number:
MFCD00161484
UNSPSC Code:
12352202
eCl@ss:
42020611
PubChem Substance ID:
24891466
NACRES:
NA.32

주요 문서

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제품 이름

Angiotensin II human, ≥93% (HPLC), powder

SMILES string

[nH]1cncc1C[C@H](NC(=O)C(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)CCCNC(=N)N)C(C)C)Cc4ccc(cc4)O)[C@H](CC)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](Cc3ccccc3)C(=O)O

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

biological source

synthetic

assay

≥93% (HPLC)

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

concentration

≤100%

technique(s)

cell culture | mammalian: suitable

impurities

1.2-10.4% acetate

solubility

water: 25 mg/mL, clear, colorless

UniProt accession no.

P01019

storage temp.

−20°C

Quality Level

300

Gene Information

human ... AGT(183)

Analysis Note

Peptide content not less than 75%

Application

  • Angiotensin II (angII) human has been used:
  • to study its effect on interleukin-1β–mediated islet inflammation and β-cell dysfunction.
  • to determine if angII activates specific calcineurin-dependent NFAT (nuclear factor of activated T-cells) isoforms in cardiomyocytes.
  • to study the actions of systemic angII infusions on glomerular permeability in vivo.
  • to induce abdominal aortic aneurysms (AAAs) in ApoE knockout mice for experimental studies.
  • to study the effect of Ang II infusion on atrial branched-chain amino acids (BCAAs) catabolism in male C57/BL6 mice.
  • to check the effects of angII on plasma triglyceride production and its association with insulin resistance in normal rats.

Biochem/physiol Actions

Angiotensin II (angII) is an octapeptide cardiovascular hormone which affects the activities of the heart, kidney, vasculature and brain. AngII in the blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, and modulation of myocardial hypertrophy, renal failure and fibrosisAngII plays a key role in the regulation of blood pressure via the renin-angiotensin-aldosterone (RAAS) pathway.

Features and Benefits

The purity of our angiotensin II human, Ang II, is verified to assure your experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.

General description

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH3COOH · H2O
Research area: Cell Signaling

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
0000526072
0000526072
0000525579
0000525579
0000524780

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Mengxia Fu et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(8), 1629-1644 (2019-06-14)
Periaortic arch adipose tissue (PAAT) plays critical roles in regulating vascular homeostasis; however, its anatomic features, developmental processes, and origins remain unclear. Approach and Results: Anatomic analysis and genetic lineage tracing of Wnt1 (wingless-type MMTV [mouse mammary tumor virus] integration
Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.
Vaughan DE et al.
The Journal of Clinical Investigation, 95, 995-995 (1995)
Angiotensin II as a pro-inflammatory mediator.
Phillips MI and Kagiyama S
Current Opinion in Investigational Drugs, 3, 569-569 (2002)
Yifei Zhou et al.
Biochemical and biophysical research communications, 634, 138-144 (2022-10-16)
In recent years, abdominal aortic aneurysm (AAA) lesions have become one of the important diseases that threaten public health. Related studies have confirmed that the occurrence of abdominal aortic aneurysms is related to inflammatory stress, cell apoptosis, and elastic fiber
Angiotensin II and renal fibrosis.
Mezzano SA et al.
Hypertension, 38, 635-635 (2001)
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