B1427

H-89 dihydrochloride hydrate

Name: H-89 dihydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), powder, PKA inhibitor

동의어(들):

N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₀H₂₀BrN₃O₂S · 2HCl · xH₂O

CAS 번호:

130964-39-5

Molecular Weight:

519.28 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24278256

NACRES:

NA.77

MDL number:

MFCD11045926

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

주요 문서

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제품 이름

H-89 dihydrochloride hydrate, ≥98% (HPLC), powder

SMILES string

O.Cl.Cl.Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1

InChI

1S/C20H20BrN3O2S.2ClH.H2O/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;;/h1-10,12,15,22,24H,11,13-14H2;2*1H;1H2/b3-2+;;;

InChI key

GKFFJFGBWAGAFD-HZBIHQSRSA-N

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)

Application

H-89 dihydrochloride hydrate has been used in the inhibition of protein kinase A in Leydig cells, primary calvarial osteoblasts (pOBs), rat granulosa cell line (LH-15 cells) and human umbilical vein endothelial cells (HUVECs).

Biochem/physiol Actions

Selective, potent inhibitor of cAMP-dependent protein kinase.

H-89 dihydrochloride hydrate is a selective inhibitor of protein kinase A (PKA). It also inhibits potassium (K⁺) current in rat myocytes. It mediates Na⁺ transport by interacting with α subunits of epithelial Na⁺ channel (ENaC).

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the PKA & PKG and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

H-89 inhibits transient outward and inward rectifier potassium currents in isolated rat ventricular myocytes

Pearman C, et al.

British Journal of Pharmacology, 148(8), 1091-1098 (2006)

Hypoxia sensing through beta-adrenergic receptors

Cheong HI, et al.

JCI insight, 1(21), 179-185 (2016)

H89, an inhibitor of protein kinase A (PKA), stimulates Na+ transport by translocating an epithelial Na+ channel (ENaC) in fetal rat alveolar type II epithelium

Marunaka Y and Niisato N

Biochemical Pharmacology, 66(6), 1083-1089 (2003)

Pigment epithelium-derived factor regulation by human chorionic gonadotropin in granulosa cells

Bar-Joseph H, et al.

Reproduction (Cambridge, England), 151(2), 179-185 (2016)

Different duration of parathyroid hormone exposure distinctively regulates primary response genes Nurr1 and RANKL in osteoblasts

Choi H, et al.

Testing, 13(12), e0208514-e0208514 (2018)

모든 관련된 서류 보기

문서

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

H-89 dihydrochloride hydrate

≥98% (HPLC), powder, PKA inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI

InChI key

biological source

assay

form

color

solubility

storage temp.

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

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