B5399
(±)-Baclofen
≥98% (HPLC), GABAB receptor agonist, solid
동의어(들):
(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H12ClNO2
CAS 번호:
Molecular Weight:
213.66
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
214-486-9
MDL number:
제품 이름
(±)-Baclofen, ≥98% (HPLC), solid
InChI key
KPYSYYIEGFHWSV-UHFFFAOYSA-N
InChI
1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
SMILES string
ClC1=CC=C(C(CN)CC(O)=O)C=C1
assay
≥98% (HPLC)
form
solid
color
white to very faintly yellow
solubility
1 M HCl: 50 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... GABBR1(2550), GABBR2(9568)
rat ... Gabbr1(81657), Gabra2(29706)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
Application
(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABAB receptor agonist:
- as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
- to test its effects on in vivo motor function tests and performance of mutant mice
- to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
- to test its effect in reducing dendritic excitability in Purkinje neurons
Biochem/physiol Actions
Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABAB) agonist, baclofen may be involved in the potentiation of dendritic potassium K+ channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).
GABAB receptor agonist; skeletal muscle relaxant; antispastic agent.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Abhiram Pushparaj et al.
Behavioural brain research, 290, 77-83 (2015-05-03)
Our prior work demonstrated the involvement of the caudal granular subregion of the insular cortex in a rat model of nicotine self-administration. Recent studies in various animal models of addiction for nicotine and other drugs have identified a role for
The effects of baclofen for the treatment of gastroesophageal reflux disease: a meta-analysis of randomized controlled trials.
Li, et al.
Gastroenterology Research and Practice, 2014, 307805-307805 (2020)
The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective.
de Beaurepaire, et al.
Frontiers in Psychiatry, 9, 708-708 (2021)
Di Liu et al.
Pain, 159(1), 175-175 (2017-10-28)
Increasing evidence suggests that the mesolimbic reward system plays critical roles in the regulation of depression and nociception; however, its circuitry and cellular mechanisms remain unclear. In this study, we investigated the output-specific regulatory roles of dopaminergic (DA) neurons within
Andrés P Varani et al.
Psychopharmacology, 231(15), 3031-3040 (2014-02-21)
Nicotine is a major active ingredient in tobacco and plays a major role in tobacco addiction. In rodents, repeated nicotine administration produces behavioral responses related to its addictive properties, such as reinforcing effects and physical dependence. The aim of the
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