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B9935

BMS-345541

Name: BMS-345541
Brand: SIGMA

≥98% (HPLC), powder

동의어(들):

N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₄H₁₇N₅ · HCl

CAS 번호:

547757-23-3

Molecular Weight:

291.78

NACRES:

NA.77

PubChem Substance ID:

24724429

UNSPSC Code:

12352200

MDL number:

MFCD07784499

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

기술 서비스

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도움 문의

속성

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

DMSO: 18 mg/mL, H₂O: insoluble

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

Cl[H].Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1

InChI

1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H

InChI key

MIDKPVLYXNLFGZ-UHFFFAOYSA-N

설명

Application

BMS-345541 has been used:

as an IκB kinase (IKK) complex inhibitor to study its effects on the interferon-γ (IFN-γ) production by natural killer (NK) cells
as an IKK inhibitor to study its effects on the expression of eotaxin and monocyte chemoattractant protein-1 (MCP-1) mRNA in gingival fibroblasts
as nuclear factor κB (NF-κB) pathway inhibitor to study its effects on tumor necrosis factor α (TNFα) production in human oral squamous carcinoma cells

Biochem/physiol Actions

BMS-345541 is an IKB kinase (IKK) allosteric site inhibitor.

BMS-345541 possesses anti-inflammatory properties. It also blocks the nuclear factor κB (NF-κB)-dependent transcription of pro-inflammatory cytokines. BMS-345541 possesses anti-inflammatory activity and plays a role in arresting bone erosion in certain animal models.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.