C0166
Cys-Gly
≥85% (TLC), suitable fo HPLC
동의어(들):
L-cysteinyl-glycine
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C5H10N2O3S
CAS 번호:
Molecular Weight:
178.21
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
제품 이름
Cys-Gly, ≥85% (TLC)
Quality Level
assay
≥85% (TLC)
form
solid
technique(s)
HPLC: suitable
storage temp.
−20°C
SMILES string
NC(CS)C(=O)NCC(O)=O
InChI
1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)
InChI key
ZUKPVRWZDMRIEO-UHFFFAOYSA-N
General description
Cys-Gly, a dipeptide is a catabolic byproduct of glutathione.
Application
Cys-Gly has been used for derivatization by p-hydroxymercury benzoate (PHMB) for calibration of reversed phase chromatography coupled on-line and sequentially with a UV−visible diode array detector (RPLC-DAD).
Biochem/physiol Actions
Cys-Gly is a precursor for glutathione biosynthesis in the neurons. It favors reactive oxygen species generation in the presence of transition metal ions. A normal level of cys-gly is essential for normal cellular function.
L-Cysteine-L-Glycine (Cys-Gly) is used in studies on the homeostasis of glutathione. Cys-Gly is an important molecule for study in the areas of thiol homeostasis, oxidative stress and metals management.
Other Notes
Glutathione fragment
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
저장 등급
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Werner Siems et al.
Archives of biochemistry and biophysics, 503(2), 248-252 (2010-09-02)
Intracellular metabolism of 4-hydroxy-2-nonenal (HNE), a major product and mediator of oxidative stress and inflammation, is analyzed in resting and fMLP-stimulated human polymorphonuclear leukocytes (PMNL), where this compound is generated during activation of the respiratory burst. HNE consumption rate in
Rafał Głowacki et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(28), 3400-3404 (2009-06-30)
A fully automated HPLC method for the simultaneous determination of total thiols in plasma samples has been developed. The method involves reductive conversion of disulfides to their reduced counterparts with the use of tris(2-carboxyethyl)phosphine. After reduction the newly formed sulfhydryl
Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione
Dringen R, et al.
The Journal of Neuroscience, 19(2), 562-569 (1999)