C0283
L-Carnitine hydrochloride
≥98%, synthetic
동의어(들):
(−)-β-Hydroxy-γ-(trimethylammonio)butyrate, Vitamin BT
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
(CH3)3N+CH2CH(OH)CH2CO2H · Cl-
CAS 번호:
Molecular Weight:
197.66
NACRES:
NA.79
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
229-663-6
MDL number:
제품 이름
L-Carnitine hydrochloride, synthetic, ≥98%
InChI key
JXXCENBLGFBQJM-FYZOBXCZSA-N
InChI
1S/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/t6-;/m1./s1
SMILES string
[Cl-].C[N+](C)(C)C[C@H](O)CC(O)=O
biological source
synthetic
assay
≥98%
form
powder
color
white
mp
142 °C
application(s)
cell analysis
Quality Level
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Application
L-Carnitine hydrochloride has been used to study ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5. It has also been used to allow the entry of palmitic acid into the mitochondria.
Biochem/physiol Actions
Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.
Carnitine is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
K Kasperek et al.
Polish journal of veterinary sciences, 21(4), 811-813 (2019-01-04)
The aim of our study was to determine the influence of L-carnitine (L-CAR) on the cellular parameters of hen erythrocytes during a 48 hour exposure to L-CAR at concentrations of 25, 50 and 100 µg/mL in nutrient-deficient medium. Cell morphology
R E L Cabral et al.
Andrology, 6(1), 236-246 (2017-10-04)
Doxorubicin has been largely used in anticancer therapy in adults, adolescents, and children. The efficacy of l-carnitine as an antioxidant substance has been confirmed both in humans and rats. Carnitine, present in testis and epididymis, is involved in sperm maturation.
Giulia Mollica et al.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 52(3), 314-323 (2019-10-15)
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disorder. NAFLD, associated lipotoxicity, fibrosis, oxidative stress, and altered mitochondrial metabolism, is responsible for systemic inflammation, which contributes to organ dysfunction in extrahepatic tissues, including the heart. We
Isabelle Lelong-Rebel et al.
Anticancer research, 28(1A), 55-68 (2008-04-04)
Two chemosensitive cell lines, LoVo-fusoid (LoVo-f) and LoVo-small cells (LoVo-sc) were derived from the original LoVo cell line. These two variants and the multidrug-resistant (MDR) cell line LoVo-Dox were screened for various properties. In non-permeabilized cells, only LoVo-sc showed mucin-2
Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: Gain-of-function by interchange of selected amino acids
Petra Bacher.
Biochimica et Biophysica Acta, 1788(12), 2594-2602 (2009)
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