C0869

Celastrol

Name: Celastrol
Brand: SIGMA

≥98% (HPLC), solid, antioxidant

동의어(들):

10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₉H₃₈O₄

CAS 번호:

34157-83-0

Molecular Weight:

450.61

UNSPSC Code:

12352200

PubChem Substance ID:

329774823

NACRES:

NA.77

MDL number:

MFCD03424073

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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제품 이름

Celastrol, ≥98% (HPLC), solid

color

red

assay

≥98% (HPLC)

form

solid

SMILES string

CC1=C(O)C(=O)C=C2C1=CC=C3[C@@]2(C)CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(O)=O

InChI key

KQJSQWZMSAGSHN-JJWQIEBTSA-N

InChI

1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

−20°C

Quality Level

100

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Application

Celastrol has been:

used intraperitoneally to inject into experimental mice to study its role in nonalcoholic fatty liver disease (NAFLD)
used in culture medium to study its effect on lipopolysaccharide-induced inflammatory injury in human keratinocyte cell culture
used to study its effect in vitro and in vivo in VCaP cells

Biochem/physiol Actions

Celastrol is a potent antioxidant, and anti-inflammatory agent.

Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).

Celastrol is a quinone methide triterpene naturally present in Tripterygium wilfordii. It is useful in treating rheumatoid arthritis. Celastrol prevents the action of proteasome and nuclear factor Κb.

저장 등급

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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문서 라이브러리 방문

Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

Zhang Y, et al.

Molecular Metabolism, 6(1), 138-147 (2017)

Tripterine alleviates LPS-induced inflammatory injury by up-regulation of miR-146a in HaCaT cells

Xiong Y, et al.

Biomedicine and Pharmacotherapy, 105, 798-804 (2018)

The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis.

Erin M O'Leary et al.

Molecular genetics and metabolism, 107(1-2), 173-185 (2012-08-18)

Sialidosis is an autosomal recessive disorder caused by a dysfunctional Sialidase enzyme. Categorised into two phenotypes, Sialidosis type I and II, Sialidosis is a highly heterogeneous disorder with varying ages of onset and pathologies. Currently, there is no viable therapy

Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis.

Mengfei Liu et al.

Nature communications, 12(1), 4560-4560 (2021-07-29)

Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated cytokine pathways leading to elevated chemokine expression. Super-enhancers are expansive regulatory elements driving augmented gene expression. Here, we explore the mechanistic role of super-enhancers linking cytokine TNFα with chemokine

Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.

Radhamani Kannaiyan et al.

Cancer letters, 303(1), 9-20 (2010-12-21)

Identification of active constituents and their molecular targets from traditional medicine is an enormous opportunity for modern pharmacology. Celastrol is one such compound that was originally identified from traditional Chinese medicine (Thunder of God Vine) almost three decades ago and

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DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Celastrol

≥98% (HPLC), solid, antioxidant

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

color

assay

form

SMILES string

InChI key

InChI

solubility

storage temp.

Quality Level

관련 카테고리

설명

Application

Biochem/physiol Actions

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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