C127
CNQX
≥98% (HPLC), AMPA/kainate glutamate receptor antagonist, solid
동의어(들):
6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C9H4N4O4
CAS 번호:
Molecular Weight:
232.15
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
CNQX, ≥98% (HPLC), solid
SMILES string
[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N
InChI
1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
InChI key
RPXVIAFEQBNEAX-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
yellow
solubility
DMSO: >10 mg/mL, H2O: insoluble
Quality Level
Gene Information
rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409)
관련 카테고리
Application
CNQX has been used:
- as an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate blocker to study its effects on cytoneme formation in pluripotent embryonic stem cells (pESCs)
- glutamate blocker to reduce the synaptic input during current-clamp recordings in central antennal lobe neurons
- as a non-N-methyl-D-aspartate (NMDA) receptor blocker to study its effects on the heart rate in rats
Biochem/physiol Actions
Potent, competitive AMPA/kainate glutamate receptor antagonist.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Haiyan Li et al.
Frontiers in cellular neuroscience, 11, 324-324 (2017-11-11)
Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that
Binbin Yan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)
Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and
Emmanuelle Berret et al.
Nature communications, 8(1), 557-557 (2017-09-17)
Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation
Ira Espuny-Camacho et al.
Neuron, 77(3), 440-456 (2013-02-12)
The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), cultured
Sutirtha Ray et al.
Pain, 160(4), 954-964 (2019-01-03)
Paracetamol (acetaminophen, APAP) is one of the most frequently used analgesic agents worldwide. It is generally preferred over nonsteroidal anti-inflammatory drugs because it does not cause typical adverse effects resulting from the inhibition of cyclooxygenases, such as gastric ulcers. Nevertheless
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