C2020

α-Cyano-4-hydroxycinnamic acid

Name: &#945;-Cyano-4-hydroxycinnamic acid
Brand: SIGMA

≥98% (TLC), powder, monocarboxylic acid transport inhibitor

동의어(들):

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

Linear Formula:

HOC₆H₄CH=C(CN)CO₂H

CAS 번호:

28166-41-8

Molecular Weight:

189.17

NACRES:

NA.77

PubChem Substance ID:

24892459

UNSPSC Code:

12352106

EC Number:

248-879-1

MDL number:

MFCD00004204

Beilstein/REAXYS Number:

3271427

Assay:

≥98% (TLC)

Form:

powder

Quality level:

300

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제품 이름

α-Cyano-4-hydroxycinnamic acid, ≥98% (TLC), powder

InChI key

AFVLVVWMAFSXCK-VMPITWQZSA-N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

SMILES string

OC(=O)\C(=C\c1ccc(O)cc1)C#N

assay

≥98% (TLC)

form

powder

color

yellow

mp

245-250 °C (lit.)

solubility

H₂O: slightly soluble, methanol: water: soluble, polar organic solvents: soluble

storage temp.

2-8°C

Quality Level

300

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Application

α-Cyano-4-hydroxycinnamic acid has been used to block monocarboxylate transporters.

α-Cyano-4-hydroxycinnamic acid is a useful hydrophobic matrix solution for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Antibiotics, peptide nucleic acids (a new class of DNA mimics), and proteins with masses as high as 66,000 Da have been successfully analyzed by using this as a matrix solution.

Biochem/physiol Actions

α-Cyano-4-hydroxycinnamic acid acts as a specific inhibitor of monocarboxylic acid transport, including lactate and pyruvate transport. It is also reported to block β-cell apical anion exchange (IC₅₀ of 2.4 mM).

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1B

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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문서 라이브러리 방문

An automated system for delivery of an unstable transcription factor to hematopoietic stem cell cultures.

Elizabeth Csaszar et al.

Biotechnology and bioengineering, 103(2), 402-412 (2009-03-07)

An automated delivery system for cell culture applications would permit studying more complex culture strategies and simplify measures taken to expose cells to unstable molecules. We are interested in understanding how intracellular TAT-HOXB4 protein concentration affects hematopoietic stem cell (HSC)

Reduced glucose metabolism enhances the glutamate-evoked release of arachidonic acid from striatal neurons.

R J Williams et al.

Neuroscience, 74(2), 461-468 (1996-09-01)

Glucose deprivation potentiates the glutamate receptor-evoked release of arachidonic acid from cultured mouse striatal neurons. In this study we investigated whether this potentiation would be modified by the end-products of glycolysis. These enhanced responses were completely reversed by the addition

Adaptive cellular mechanisms in response to Glutamine-starvation

Eliasen MM, et al.

Frontiers in Bioscience, 11, 3199-3211 (2006)

Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots.

U Schneider et al.

Neuroscience, 53(4), 1153-1162 (1993-04-01)

Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate. In the present study, we used double-barrelled pH-sensitive microelectrodes to investigate the link between lactate

L-Lactate Promotes Adult Hippocampal Neurogenesis

Lev-Vachnish Y, et al.

Frontiers in Neuroscience, 13 (2019)

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α-Cyano-4-hydroxycinnamic acid

≥98% (TLC), powder, monocarboxylic acid transport inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

InChI

SMILES string

assay

form

color

mp

solubility

storage temp.

Quality Level

관련 카테고리

설명

Application

Biochem/physiol Actions

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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