General description
Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.
Application
Compound 48/80 has been used:
- to stimulate hemocytes for histamine release for measurement in ELISA and flow cytometry
- to induce mast cell degranulation
- to induce anaphylactic activity, dermatitis, pruritis, inflammation in mice
Biochem/physiol Actions
Compound 48/80 (C 48/80) is a hypotensive agent, which promotes release of histamine. C 48/80 reduces the phagocytic ability of hemocytes in Styela plicata. C 48/80 promotes degranulation of mast cells. It Inhibits calmodulin, phospholipase C, endoplasmic reticulum (ER) Ca2+ ATPase and activates G proteins.
Preparation Note
Condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
문서
지질 신호전달 연구를 위한 생체 활성 저분자
Discover Bioactive Small Molecules for Lipid Signaling Research
관련 콘텐츠
Instructions
Histamine regulates the inflammatory response of the tunicate Styela plicata
Garcia-Garcia E, et al.
Developmental and Comparative Immunology, 46(2), 382-391 (2014)
Development of a short-term canine full-thickness skin organ culture method under serum-free conditions
Abramo F, et al.
American Journal of Animal and Veterinary Sciences, 11(2), 61-69 (2016)
Antiallergic activity of Aristolochia bracteolata Lank in animal model
Chitme HR, et al.
Indian Journal of Experimental Biology, 48, 46-52 (2010)