C2615
Chromanol 293B
≥98% (HPLC), potassium channel protein (KvLQT1) inhibitor, powder
동의어(들):
trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H20N2O4S
CAS 번호:
Molecular Weight:
324.40
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
Chromanol 293B, ≥98% (HPLC), powder
SMILES string
CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)Oc2ccc(cc12)C#N
InChI
1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
InChI key
HVSJHHXUORMCGK-UONOGXRCSA-N
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: 18 mg/mL
storage temp.
−20°C
Quality Level
General description
Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).
Application
Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.
Biochem/physiol Actions
Blocker of the slow delayed rectifier K+ current via KCNQ1 channels
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
A Varro et al.
The Journal of physiology, 523 Pt 1, 67-81 (2000-02-16)
1. The relative contributions of the rapid and slow components of the delayed rectifier potassium current (IKr and IKs, respectively) to dog cardiac action potential configuration were compared in ventricular myocytes and in multicellular right ventricular papillary muscle and Purkinje
Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels
Yang IC, et al.
Journal of Pharmacology and Experimental Therapeutics, 294(3), 955-962 (2000)
CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels
Jantarajit W, et al.
American Journal of Physiology. Cell Physiology, 313(1), C118-C129 (2017)
J E Matos et al.
Acta physiologica (Oxford, England), 189(3), 251-258 (2007-02-20)
Colonic crypts are the site of Cl- secretion. Basolateral K+ channels provide the driving force for luminal cystic fibrosis transmembrane regulator-mediated Cl- exit. Relevant colonic epithelial K+ channels are the intermediate conductance Ca2+-activated K(Ca)3.1 (SK4) channel and the cAMP-activated K(V)7.1
C Lengyel et al.
British journal of pharmacology, 132(1), 101-110 (2001-01-13)
1. The effects of I(Ks) block by chromanol 293B and L-735,821 on rabbit QT-interval, action potential duration (APD), and membrane current were compared to those of E-4031, a recognized I(Kr) blocker. Measurements were made in rabbit Langendorff-perfused whole hearts, isolated
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