C2901
Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated
≥95% (HPLC), powder
동의어(들):
CCK-8, non-sulfated
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크기 선택
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C49H62N10O13S2
CAS 번호:
Molecular Weight:
1063.21
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Quality Level
assay
≥95% (HPLC)
form
powder
UniProt accession no.
storage temp.
−20°C
SMILES string
CSCCC(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CC(O)=O)C(=O)NCC(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(CCSC)C(=O)NC(CC(O)=O)C(=O)NC(Cc4ccccc4)C(N)=O
InChI
1S/C49H62N10O13S2/c1-73-18-16-34(55-47(70)37(21-28-12-14-30(60)15-13-28)58-44(67)32(50)23-41(62)63)45(68)53-26-40(61)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(71)56-35(17-19-74-2)46(69)59-39(24-42(64)65)49(72)57-36(43(51)66)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52,60H,16-24,26,50H2,1-2H3,(H2,51,66)(H,53,68)(H,54,61)(H,55,70)(H,56,71)(H,57,72)(H,58,67)(H,59,69)(H,62,63)(H,64,65)
InChI key
OIXQINQYMGNCII-UHFFFAOYSA-N
Gene Information
human ... CCK(885)
Application
Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated has been used in the specificity testing against gastrin and pepsinogen I proteins.
Biochem/physiol Actions
Biologically inactive form of CCK-8; CCKB/gastrin receptor agonist that has no activity at the CCKA receptor.
Cholecystokinin (CCK) is a 115 amino acid preprohormone and a neurotransmitter. It exists in many isoforms. The octapeptide of CCK (CCK-8S) is the most abundant form. CCK is mapped to human chromosome 3p22.1. CCK interacts with receptors of the gastrointestinal tract and nervous system. Polymorphisms in the CCK is implicated in hallucinations in patients with Parkinson′s disease. CCK plays a key role in the activation of the calcineurin-regulated nuclear factor of activated T-cells (NFATs).
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Genetic substrates of psychosis in patients with Parkinson's disease: a critical review.
Lenka A, et al.
Journal of the Neurological Sciences, 364(5), 33-41 (2016)
Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies.
Gales C, et al.
Molecular Pharmacology, 63(5), 973-982 (2003)
Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo.
Gurda GT, et al.
Molecular Biology of the Cell, 19(1), 198-206 (2008)