C2920
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
≥98% (HPLC), powder, Mitophagy inducer
동의어(들):
FCCP, Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
CF3OC6H4NHN=C(CN)2
CAS 번호:
Molecular Weight:
254.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-730-8
MDL number:
Beilstein/REAXYS Number:
664446
제품 이름
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, ≥98% (HPLC), powder
InChI key
BMZRVOVNUMQTIN-UHFFFAOYSA-N
InChI
1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
SMILES string
FC(F)(F)Oc1ccc(N\N=C(/C#N)C#N)cc1
assay
≥98% (HPLC)
form
powder
color
yellow
mp
174-175 °C (dec.) (lit.)
solubility
95% ethanol: soluble
storage temp.
2-8°C
Quality Level
General description
FCCP is a protonophore (H+ ionophore) and uncoupler of oxidative phosphorylation in mitochondria. It is capable of depolarizing plasma and mitochondrial membranes. FCCP has been shown to have several effects on cellular calcium. It is also reported to inhibit a background K+ current and induce a small inward current, reduce pH by 0.1 unit, and induce a rise of intracellular [Na+]. FCCP stimulates Mg2+-ATPase activity, inhibits β-amyloid production, and mimics the effect of selective glutamate agonist N-methyl-D-aspartate (NMDA) on mitochondrial superoxide production.
Application
Carbonylcyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) has been used as an uncouplerin cell culture: to study its effects on murine thermogenic adipocytes, tostudy its effects on β-oxidation in mouse mitochondria, to study its effects on the metabolism in bone marrow-derived dendriticcells from mouse
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Kyu-Sang Park et al.
Pflugers Archiv : European journal of physiology, 443(3), 344-352 (2002-01-26)
We investigated the effects of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP), a protonophore and uncoupler of mitochondrial oxidative phosphorylation in mitochondria, on plasma membrane potential and ionic currents in bovine aortic endothelial cells (BAECs). The membrane potential and ionic currents of BAECs were
Isa Mambetsariev et al.
Journal of clinical medicine, 8(7) (2019-07-19)
Small cell lung cancer (SCLC) is an aggressive neuroendocrine disease with an overall 5 year survival rate of ~7%. Although patients tend to respond initially to therapy, therapy-resistant disease inevitably emerges. Unfortunately, there are no validated biomarkers for early-stage SCLC
Aleksandar Rakovic et al.
Cell death and differentiation, 26(8), 1428-1441 (2018-10-31)
The Parkinson's disease (PD)-related ubiquitin ligase Parkin and mitochondrial kinase PINK1 function together in the clearance of damaged mitochondria. Upon mitochondrial depolarization, Parkin translocates to mitochondria in a PINK1-dependent manner to ubiquitinate outer mitochondrial membrane proteins. According to the current
Sunjin Lee et al.
Ecotoxicology and environmental safety, 182, 109377-109377 (2019-06-30)
The measurement of oxygen consumption rate (OCR) provides a comprehensive understanding of mitochondrial metabolism. However, no study has been conducted to investigate the mitochondrial dysfunction caused by organophosphate flame retardants (OPFRs). The objectives of this study were to optimize the
Catherine G Burke et al.
Scientific reports, 9(1), 11489-11489 (2019-08-09)
Early life environmental exposures drive lasting changes to the function of the immune system and can contribute to disease later in life. One of the ways environmental factors act is through cellular receptors. The aryl hydrocarbon receptor (AHR) is expressed
문서
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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