C3025
(±)-Chlorpheniramine maleate salt
≥99% (perchloric acid titration)
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C16H19ClN2 · C4H4O4
CAS 번호:
Molecular Weight:
390.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
204-037-5
MDL number:
InChI key
DBAKFASWICGISY-BTJKTKAUSA-N
InChI
1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
assay
≥99% (perchloric acid titration)
form
powder
mp
130-135 °C (lit.)
originator
Bayer
Quality Level
Gene Information
human ... HRH1(3269)
General description
Chlorpheniramine maleate (CPM)/(3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine is an alkylamine antihistamine.
Application
(±)-Chlorpheniramine maleate salt has been used:
- as H1 receptor antagonist to determine the receptor function
- to block the effect of compound 48/80 on plasma IGF-I
- as a standard for fast sensing and determination by sequential injector coupled with potentiometer
Biochem/physiol Actions
H1 Histamine receptor antagonist.
Chlorpheniramine maleate (CPM) can prevent rhinitis and urticaria. It is used to cure several allergic conditions. This antihistamine is used in small-animal veterinary practices.
Features and Benefits
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord
Zhang L, et al.
Molecular Brain, 7(1), 25-25 (2014)
Functionalized Fe3O4 Magnetic Nanoparticle Potentiometric Detection Strategy versus Classical Potentiometric Strategy for Determination of Chlorpheniramine Maleate and Pseudoephedrine HCl
Moustafa AA, et al.
Journal of Analytical Methods in Chemistry (2019)
Endogenous histamine reduces plasma insulin-like growth factor I via H1 receptor-mediated pathway in the rat
Liao W, et al.
European Journal of Pharmacology, 374(3), 471-476 (1999)
Sensing of chlorpheniramine in pharmaceutical applications by sequential injector coupled with potentiometer
Saleh TA
Journal of Pharmaceutical Analysis, 1(4), 246-250 (2011)
Veerachamy Alagarsamy et al.
Bioorganic & medicinal chemistry letters, 15(7), 1877-1880 (2005-03-23)
A series of novel 1-substituted-4-phenyl-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones 7 were synthesized by the cyclization of 2-hydrazino-3-phenylquinazolin-4(3H)-one 6 with various one carbon donors. The starting material 2-hydrazino-3-phenylquinazolin-4(3H)-one 6, was synthesized from aniline 1 by a novel innovative route. When tested for their in vivo
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