C4042

Captopril

Name: Captopril
Brand: SIGMA

≥98% (HPLC), powder, angiotensin converting enzyme inhibitor

동의어(들):

N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₉H₁₅NO₃S

CAS 번호:

62571-86-2

Molecular Weight:

217.29

NACRES:

NA.77

PubChem Substance ID:

57654003

UNSPSC Code:

12352200

EC Number:

263-607-1

MDL number:

MFCD00168073

Beilstein/REAXYS Number:

477887

주요 문서

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제품 이름

Captopril, ≥98% (HPLC), powder

InChI key

FAKRSMQSSFJEIM-RQJHMYQMSA-N

InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

SMILES string

C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

biological source

synthetic

assay

≥98% (HPLC)

form

powder

color

white to off-white

mp

104-108 °C (lit.)

solubility

water: 100 mg/mL, clear to very slightly hazy, colorless to faintly yellow

originator

Bristol-Myers Squibb

storage temp.

room temp

Quality Level

100

Gene Information

human ... ACE(1636), AGTR1(185), AGTR2(186), ECE1(1889)
rat ... Ace(24310)

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Application

Captopril has been used:

to examine the influence of timing of captopril treatment on efficacy in transverse aortic constriction (TAC) mice
as an angiotensin-converting enzyme inhibitor and orally administered to unrestrained Wistar Kyoto rats in an approach to study its effects of angiogenesis inhibition and interdependency with other drugs
used as a positive control in spectrophotometric assay to study the angiotensin-converting enzyme inhibitory activity

Biochem/physiol Actions

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Captopril is known to decrease the cardiovascular complications arising due to myocardial infarction. It is an effective drug in treating diabetic nephropathy and renal disease. Captopril acts by reducing cardiac related inflammation, fibrosis and calcification.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08

signalword

Danger

hcodes

H341,H360F

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 2 - Repr. 1B

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

ACE Inhibitory Properties and Phenolics Profile of Fermented Flours and of Baked and Digested Biscuits from Buckwheat.

Henryk Zieliński et al.

Foods (Basel, Switzerland), 9(7) (2020-07-03)

The angiotensin converting enzyme (ACE) inhibitory activity and phenolics profile of fermented flours and of baked and digested buckwheat biscuits was studied. The fermentation of buckwheat flour by select lactic acid bacteria (LAB) caused a decrease in ACE inhibitory activity

Captopril prevents experimental autoimmune myocarditis

Godsel LM, et al.

Journal of Immunology, 171(1), 346-352 (2003)

The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy

Martino TA, et al.

Journal of the American College of Cardiology, 57(20), 2020-2028 (2011)

The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy.

Tami A Martino et al.

Journal of the American College of Cardiology, 57(20), 2020-2028 (2011-05-14)

Our objective was to test the hypothesis that there is a significant diurnal variation for the therapeutic benefit of angiotensin-converting enzyme (ACE) inhibitors on pressure-overload cardiovascular hypertrophy. Physiological and molecular processes exhibit diurnal rhythms that may affect efficacy of disease

Identification of antihypertensive peptides derived from low molecular weight casein hydrolysates generated during fermentation by Bifidobacterium longum KACC 91563

Ha GE, et al.

Korean journal for food science of animal resources, 35(6), 738-738 (2015)

모든 관련된 서류 보기

문서

Critical Inhibitor Characteristics to Consider

Discover critical characteristics to consider when working with enzyme inhibitors, such as cell permeability, the prozone effect, and Lipinski’s rule of 5.

중요하게 고려해야 할 억제제 특성

세포 투과성, 프로존 효과, 리핀스키의 5 규칙 등의 효소 억제제로 작업 시 중요하게 고려해야 할 특성을 알아보세요.

Discover Bioactive Small Molecules for ADME/Tox

Captopril

≥98% (HPLC), powder, angiotensin converting enzyme inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

InChI

SMILES string

biological source

assay

form

color

mp

solubility

originator

storage temp.

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

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