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Merck

C4382

Carbamoylcholine chloride

≥98% (titration), Non-selective cholinergic agonist, crystalline

동의어(들):

(2-Hydroxyethyl)trimethylammonium chloride carbamate, Carbachol, Carbamylcholine chloride

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
NH2COOCH2CH2N(Cl)(CH3)3
CAS 번호:
51-83-2
Molecular Weight:
182.65
NACRES:
NA.77
PubChem Substance ID:
24277829
UNSPSC Code:
12352200
EC Number:
200-127-3
MDL number:
MFCD00012011
Beilstein/REAXYS Number:
3917459

주요 문서

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제품 이름

Carbamoylcholine chloride, ≥98% (titration), crystalline

InChI

1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H

InChI key

AIXAANGOTKPUOY-UHFFFAOYSA-N

SMILES string

[Cl-].C[N+](C)(C)CCOC(N)=O

assay

≥98% (titration)

form

crystalline

color

white

mp

210 °C (dec.) (lit.)

solubility

H2O: 1 g/mL
ethanol: 20 mg/mL

Quality Level

100

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), CHRNA2(1135)
mouse ... Chrm1(12669)
rat ... Chrm1(25229), Chrm2(81645), Chrm3(24260), Chrna2(170945), Chrna3(25101), Chrna4(25590)

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관련 카테고리

Application

Carbamoylcholine chloride has been used:
  • to stimulate insulin secretion in transgenic mice
  • to induce contraction of undifferentiated and differentiated human adipose-derived stem cells (hASCs)
  • to mediate constriction of iris in pupillary light reflex studies in mice

Biochem/physiol Actions

Carbachol elicits tear fluid secretion by interacting with muscarinic receptors. It is an analog of acetylcholine and an antiglaucoma drug. In ciliary processes, carbachol along with nitric oxide (NO) regulates Na+ and K+-ATPase activity. It stimulates insulin vesicles transport to the secretory site to increase insulin secretion.
Non-selective cholinergic agonist that is resistant to the action of cholinesterases; inhibits apoptotic death of cultured neurons, and may induce apoptosis in thymocytes.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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시험 성적서(COA)

Lot/Batch Number
BCCM7389
BCCK0644
BCCH5511
BCCJ5652
BCCG5823

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Role of the non-neuronal cholinergic system in the eye: a review
Duncan G and Collison DJ
Life Sciences, 72(18-19), 2013-2019 (2003)
Carbachol and nitric oxide inhibition of Na, K-ATPase activity in bovine ciliary processes
Ellis DZ, et al.
Investigative Ophthalmology & Visual Science, 42(11), 2625-2631 (2001)
Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells
Wang C, et al.
Tissue Engineering: Part A, 19(3-4), 415-425 (2012)
Anne Cathrine Nøhr et al.
Scientific reports, 9(1), 3802-3802 (2019-03-09)
GPR139 is an orphan G protein-coupled receptor (GPCR) that is primarily expressed in the brain in regions known to regulate motor control and metabolism. Here, we screened a diverse 4,000 compound library in order to identify GPR139 agonists. We identified
BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion
Goulley J, et al.
Cell Metabolism, 5(3), 207-219 (2007)
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