C5423
Clenbuterol hydrochloride
≥95% (TLC), powder, β2-adrenoceptor agonist
동의어(들):
4-Amino-α-(t-butylaminomethyl)-3,5-dichlorobenzyl alcohol hydrochloride
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H18Cl2N2O · HCl
CAS 번호:
Molecular Weight:
313.65
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-643-7
MDL number:
제품 이름
Clenbuterol hydrochloride, ≥95%
InChI
1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H
InChI key
OPXKTCUYRHXSBK-UHFFFAOYSA-N
SMILES string
Cl.CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1
assay
≥95%
form
powder
drug control
Home Office Schedule 4.2
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADRB2(154)
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Application
Clenbuterol hydrochloride has been used:
- as an agonist for β-adrenergic receptor (β-AR) from chick skeletal muscle
- to induce hypertrophic effects in masseter, digastric, and temporalis muscles of rat
- as a reference β-agonist standard in tandem mass spectrometry(MS-MS)
Biochem/physiol Actions
Clenbuterol hydrochloride is a β2-adrenoceptor agonist and bronchodilator. It is effective in improving peak expiratory flow rate (PEFR) in asthma patients. Clenbuterol is also a performance-enhancing drug as it stimulates the central nervous system and improves oxygen transport. Clenbuterol elicits cardio protective functionality in patients with dilated cardiomyopathy.
signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Repr. 1B
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
A trial of clenbuterol in bronchial asthma.
Anderson G and Wilkins E
Thorax, 32(6), 717-719 (1977)
C A Izeboud et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 48(9), 497-502 (1999-10-16)
To investigate the suppressive effects of the beta-agonist clenbuterol on the release of TNF-alpha and IL-6 in a lipopolysaccharide (LPS)-model of inflammation, both in vitro and in vivo. Human U-937 cell line (monocyte-derived macrophages), and male Wistar rats (200-250 g).
Jelka Pleadin et al.
Meat science, 86(3), 733-737 (2010-07-30)
The aim of this study was to determine the level of clenbuterol residues in muscle tissue of pigs after repeat administration in a growth-promoting dose. An anabolic dose of clenbuterol (20 μg/kg body mass per day) was administered orally to
Vipin Arora et al.
Molecular pain, 17, 1744806921997206-1744806921997206 (2021-04-09)
Beta 2 adrenergic receptor (β2 AR) activation in the central and peripheral nervous system has been implicated in nociceptive processing in acute and chronic pain settings with anti-inflammatory and anti-allodynic effects of β2-AR mimetics reported in several pain states. In
beta2-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats
Zhang Q, et al.
British Journal of Pharmacology, 160(6), 1561-1572 (2010)
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