C5865
CD437
≥98% (HPLC), retinoic acid receptor (RAR)γ-selective agonist, solid
동의어(들):
6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid, AHPN
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C27H26O3
CAS 번호:
Molecular Weight:
398.49
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
CD437, ≥98% (HPLC), solid
SMILES string
OC(=O)c1ccc2cc(ccc2c1)-c3ccc(O)c(c3)C45CC6CC(CC(C6)C4)C5
InChI key
LDGIHZJOIQSHPB-UHFFFAOYSA-N
InChI
1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)
assay
≥98% (HPLC)
form
solid
impurities
~0.5 mol/mol water
color
yellow
mp
271.6-276 °C
solubility
DMSO: >10 mg/mL
H2O: insoluble
storage temp.
−20°C
Quality Level
Gene Information
human ... RARA(5914), RARB(5915), RARG(5916)
Biochem/physiol Actions
CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Almudena Bosch et al.
Breast cancer research : BCR, 14(4), R121-R121 (2012-08-28)
Retinoic acid signaling plays key roles in embryonic development and in maintaining the differentiated status of adult tissues. Recently, the nuclear retinoic acid receptor (RAR) isotypes α, β and γ were found to play specific functions in the expansion and
Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis.
Fang Tan et al.
Frontiers in microbiology, 10, 2301-2301 (2019-10-28)
Enterococcus faecalis (E. faecalis), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic retinoid compound
Zuzana Machacova et al.
Nature communications, 15(1), 7375-7375 (2024-08-28)
PARP inhibitors (PARPi), known for their ability to induce replication gaps and accelerate replication forks, have become potent agents in anticancer therapy. However, the molecular mechanism underlying PARPi-induced fork acceleration has remained elusive. Here, we show that the first PARPi-induced
Mark D Long et al.
Oncogene, 38(3), 421-444 (2018-08-19)
Expression levels of retinoic acid receptor gamma (NR1B3/RARG, encodes RARγ) are commonly reduced in prostate cancer (PCa). Therefore, we sought to establish the cellular and gene regulatory consequences of reduced RARγ expression, and determine RARγ regulatory mechanisms. RARG shRNA approaches
Liyue Zhang et al.
Journal of molecular signaling, 5, 12-12 (2010-08-14)
A variety of pathways target CDKI p21WAF1/CIP1 expression at transcriptional, post-transcriptional as well as translational levels. We previously found that cell growth suppressing retinoid CD437 enhanced expression of p21WAF1/CIP1 and DNA damage inducible GADD45 proteins in part by elevating their
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