C6013
Cholesteryl hemisuccinate tris salt
anionic detergent
동의어(들):
3β-Hydroxy-5-cholestene 3-hemisuccinate, 5-Cholesten-3β-ol 3-hemisuccinate, CHEMS, CHS, Cholesteryl hydrogen succinate
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C31H50O4 · C4H11NO3
CAS 번호:
Molecular Weight:
607.86
UNSPSC Code:
12352211
eCl@ss:
39023139
PubChem Substance ID:
NACRES:
NA.77
MDL number:
SMILES string
NC(CO)(CO)CO.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O
InChI key
SLDYONDUXRBLLR-XTCKSVDZSA-N
InChI
1S/C31H50O4.C4H11NO3/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5;5-4(1-6,2-7)3-8/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33);6-8H,1-3,5H2/t21-,23+,24+,25-,26+,27+,30+,31-;/m1./s1
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
functional group
ester
shipped in
ambient
storage temp.
−20°C
Quality Level
Application
Cholesteryl hemisuccinate tris salt has been used:
- to prepare solubilization buffer for glucan synthase assay
- to prepare immunoprecipitation buffer for immobilization of opioid receptors on paramagnetic beads.
- as a membrane stabilizer for liposomes and protein synaptogyrin-1
- as a component of a folate-modified self-microemulsifying drug delivery system.
- with N-dodecyl β-D-maltoside (DDM) to solubilize erythrocyte ghosts and chemokine receptor CCR1
- for protein solubilization
Biochem/physiol Actions
Cholesteryl hemisuccinate is an ionizable anionic detergent that stabilizes large unilamellar vesicles. These liposome vesicles act as delivery agents for anticancer drugs, oligonucleotides and antibiotics. Cholesteryl succinate also reportedly exhibits antiproliferative activity and may be clinically useful as antitumor agent.
Preparation Note
Cholesteryl hemisuccinate tris salt yields clear, colorless solution in methanol at 10 mg/ml.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
David Ott et al.
Protein engineering, design & selection : PEDS, 18(3), 153-160 (2005-03-26)
Opioid receptors, like many G protein-coupled receptors (GPCRs), are notoriously unstable in detergents. We have now developed a more stable variant of the mu-opioid receptor (MOR) and also a method for the immobilization of solubilized, functional opioid receptors on a
P Mazur et al.
The Journal of biological chemistry, 271(24), 14604-14609 (1996-06-14)
In the yeast Saccharomyces cerevisiae, the family of RHO genes are implicated in the control of morphogenetic events although the molecular targets of these GTP-binding proteins remain largely unknown. The activity of 1,3-beta-D-glucan synthase, the product of which is essential
I M Hafez et al.
Biophysical journal, 79(3), 1438-1446 (2000-09-02)
The pH-dependent fusion properties of large unilamellar vesicles (LUVs) composed of binary mixtures of anionic and cationic lipids have been investigated. It is shown that stable LUVs can be prepared from the ionizable anionic lipid cholesteryl hemisuccinate (CHEMS) and the
Samantha J Allen et al.
Protein expression and purification, 66(1), 73-81 (2009-03-12)
Chemokine receptors are a specific class of G-protein-coupled receptors (GPCRs) that control cell migration associated with routine immune surveillance, inflammation and development. In addition to their roles in normal physiology, these receptors and their ligands are involved in a large
Tomoko Ohno et al.
Ocular immunology and inflammation, 27(5), 699-705 (2018-11-06)
Purpose: To investigate whether variants in the ARMC9 gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population. Methods: We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms
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