C7861
Citalopram hydrobromide
≥98% (HPLC), powder, serotonin uptake inhibitor
동의어(들):
1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H21FN2O · HBr
CAS 번호:
Molecular Weight:
405.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
261-890-6
MDL number:
제품 이름
Citalopram hydrobromide, ≥98% (HPLC)
Quality Level
InChI
1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
InChI key
WIHMBLDNRMIGDW-UHFFFAOYSA-N
SMILES string
Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
assay
≥98% (HPLC)
form
powder
solubility
chloroform: soluble, methanol: soluble
originator
Forest Labs
storage temp.
2-8°C
Gene Information
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General description
Citalopram is a bicyclic phthalene derivative. It initiates serotonergic activity, which produces antidepressant action. Citalopram hydrobromide reverses memory impairment. It is used to treat obsessive compulsive disorder, panic disorder, sociophobia and premenstrual dysphoric disorder.
Application
Citalopram hydrobromide has been used:
- to examine its effects on sirt mRNA and mammalian sirtuins (SIRT) expression in mice
- to monitor body temperature and antidepressant-like behavioral responses in the forced swim test for rats
- for 5-hydroxytryptamine (5-HT) competition uptake assays
Biochem/physiol Actions
Potent and selective serotonin uptake inhibitor (Ki = 5.4 nM); antidepressant
Features and Benefits
This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
target_organs
Central nervous system
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Citalopram hydrobromide: degradation product characterization and a validated stability-indicating LC-UV method
Sharma M, et al.
Journal of the Brazilian Chemical Society, 22(5), 836-848 (2011)
Current Treatments of Obsessive-Compulsive Disorder (2008)
Inhibition of the serotonin transporter is altered by metabolites of selective serotonin and norepinephrine reuptake inhibitors and represents a caution to acute or chronic treatment paradigms
Krout D, et al.
ACS Chemical Neuroscience, 8(5), 1011-1018 (2016)
Tomoko Soga et al.
Neuropharmacology, 59(1-2), 77-85 (2010-04-13)
Citalopram is the most potent selective serotonin reuptake inhibitor (SSRI) which is used as an antidepressant but causes sexual dysfunction. Whether citalopram induced sexual dysfunction is a result of gonadotropin-releasing hormone (GnRH), kisspeptin or RF-amide related peptide (RFRP) alteration is
The Guide to Off-label Prescription Drugs: New Uses for FDA-approved Prescription Drugs (2006)
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