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C8273

Cytochalasin D

Name: Cytochalasin D
Brand: SIGMA

From Zygosporium mansonii, ≥98% (TLC and HPLC), actin polymerization inhibitor, powder

동의어(들):

Lygosporin A, Zygosporin A

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₃₀H₃₇NO₆

CAS 번호:

22144-77-0

Molecular Weight:

507.62

NACRES:

NA.77

PubChem Substance ID:

24893039

UNSPSC Code:

12352200

EC Number:

244-804-1

MDL number:

MFCD00077706

Beilstein/REAXYS Number:

1632828

Assay:

≥98% (TLC and HPLC)

Form:

powder

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속성

제품 이름

Cytochalasin D, from Zygosporium mansonii, ≥98% (TLC and HPLC), powder

biological source

Zygosporium mansonii

Quality Segment

300

assay

≥98% (TLC and HPLC)

form

powder

solubility

DMSO: soluble, ethanol: soluble

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes

storage temp.

−20°C

SMILES string

[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4

InChI

1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1

InChI key

SDZRWUKZFQQKKV-JHADDHBZSA-N

설명

General description

Cytochalasin D is a cell-permeable fungal toxin. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Cytochalasin D inhibits smooth muscle contraction and insulin-stimulated but not basal transport of glucose.

Cytochalasin D (CytoD) is commonly used to inhibit actin dynamics and study its role in cellular processes. This fungal-derived small organic compound acts as an inhibitor of the interaction between G-actin and cofilin by binding to G-actin. Additionally, CytoD inhibits the binding of cofilin to F-actin and reduces the rate of actin polymerization and depolymerization in living cells.

Application

Cytochalasin D has been used:

to treat H9c2 cells to study the relationship between cell stiffness and the F-actin cytoskeleton
as inhibitor of receptor-mediated endocytosis to treat oligodendrocyte precursor cells (OPCs) to investigate the effect of inhibiting specific extracellular vesicle (EV) uptake pathways
in in vitro embryo culture to artificially activate oocytes

Biochem/physiol Actions

Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.

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pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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시험 성적서(COA)

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