D0564
Diphtheria Toxin
from Corynebacterium diphtheriae, ≥98% (SDS-PAGE), lyophilized powder, protein synthesis inhibitor
동의어(들):
DTx
제품 이름
Diphtheria Toxin from Corynebacterium diphtheriae, lyophilized powder, Product is in unnicked form
form
lyophilized powder
storage temp.
2-8°C
Quality Level
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Application
Diphtheria Toxin from Corynebacterium diphtheriae has been used:
- for microglia depletion to study post-traumatic stress disorder in mice
- intraperitoneally injected in transgenic mice to select the hybrids after fusion of transplanted hematopoietic stem and progenitor cells (HSPCs) during ablation
- to study its effect on eosinophil lineage-committed progenitors in an eosinophil-deficient strain of mice (iPHIL)
Biochem/physiol Actions
Diphtheria toxin is a bacterial toxin produced from Corynebacterium diphtheriae. It contains three domains that have intracellular actions. The domains are involved in the intoxication of the cell, cell-surface binding and internalization into endosomes, translocating into the cytosol across the endosome membrane and inhibiting cellular protein synthesis. Diphtheria toxin is useful in constructing biotechnological tools and therapeutics. It inhibits protein synthesis by catalyzing adenosine diphosphate (ADP)-ribosylation of the target protein in eukaryotes.
General description
Diphtheria toxin may be used as a toxin element in the construction of immunotoxin for cell-specific cytotoxicity. The translocation domain of bacterial toxins with a natural endosome escape mechanism has been used in the development of efficient nonviral vectors for applications in gene therapy.
Physical form
Lyophilized powder containing Tris and EDTA.
Preparation Note
Each vial, when reconstituted to 0.5 mL with sterile distilled water, contains ~1 mg of diphtheria toxin in 0.01 M Tris and 0.001 M Na2EDTA, pH 7.5.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Biology and molecular epidemiology of diphtheria toxin and the tox gene
The Journal of Infectious Diseases, 181 (2000)
Diphtheria toxin
The Comprehensive Sourcebook of Bacterial Protein Toxins (2015)
Benjamin J Vakoc et al.
Nature medicine, 15(10), 1219-1223 (2009-09-15)
Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous contrast agents that enable multiphoton microscopy, however, limit the ability
Allah Nawaz et al.
Nature communications, 8(1), 286-286 (2017-08-19)
Adipose tissue resident macrophages have important roles in the maintenance of tissue homeostasis and regulate insulin sensitivity for example by secreting pro-inflammatory or anti-inflammatory cytokines. Here, we show that M2-like macrophages in adipose tissue regulate systemic glucose homeostasis by inhibiting
Vicky A Tobin et al.
Nature, 464(7287), 413-417 (2010-02-26)
Many peptides, when released as chemical messengers within the brain, have powerful influences on complex behaviours. Most strikingly, vasopressin and oxytocin, once thought of as circulating hormones whose actions were confined to peripheral organs, are now known to be released
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