D0676
Dobutamine hydrochloride
≥98% (TLC), powder, α1, β1 and β2-adrenoceptor agonist
동의어(들):
(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C18H23NO3 · HCl
CAS 번호:
Molecular Weight:
337.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
256-464-1
MDL number:
제품 이름
Dobutamine hydrochloride, ≥98%
InChI key
BQKADKWNRWCIJL-UHFFFAOYSA-N
InChI
1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
SMILES string
Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2
assay
≥98%
form
powder
originator
Eli Lilly
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADRB1(153), ADRB2(154)
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Application
Dobutamine hydrochloride has been used:
- to treat mouse embryonic fibroblasts for cell death analysis
- to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
- as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging
Biochem/physiol Actions
Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.
Features and Benefits
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2
저장 등급
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Dobutamine (2018)
Workbook in Practical Neonatology, 239-239 (2014)
Programming of Schwann cells by Lats1/2-TAZ/YAP signaling drives malignant peripheral nerve sheath tumorigenesis
Wu LMN, et al.
Cancer Cell, 33(2), 292-308 (2018)
Role of p53 in cAMP/PKA pathway mediated apoptosis
Rahimi A, et al.
Apoptosis, 18(12), 1492-1499 (2013)
X Monnet et al.
British journal of anaesthesia, 111(5), 743-749 (2013-06-27)
We tested the ability of mean acceleration (Acc) and peak velocity (V peak) of the aortic velocity signal measured by oesophageal Doppler to reflect left ventricular (LV) systolic performance. We included critically ill patients in whom a fluid challenge (n=25)
관련 콘텐츠
Product Information Sheet
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