D1507
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride
≥98% (HPLC), solid, L-DOPA precursor
동의어(들):
Methyl L-DOPA hydrochloride
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H13NO4 · HCl
CAS 번호:
Molecular Weight:
247.68
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
제품 이름
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride, solid
form
solid
Quality Level
color
white to off-white
storage temp.
−20°C
SMILES string
Cl[H].COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1
InChI
1S/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/m0./s1
InChI key
WFGNJLMSYIJWII-FJXQXJEOSA-N
관련 카테고리
Application
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride has been used:
- in treating 6-hydroxydopamine induced lesions mice serotonin neurons
- in tyrosinase activity in B16F10 skin melanoma cells
- to test its neuroprotective effect in mesencephalic neurons
Biochem/physiol Actions
L-3,4-Dihydroxyphenylalanine methyl ester is a precursor to L-DOPA that crosses the blood-brain barrier. Antiparkinsonian agent L-DOPA methyl ester elicits antitumor functionality in leukemia and melanoma.
Disclaimer
Light sensitive
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Muriel Geurts et al.
Neuroscience letters, 333(2), 146-150 (2002-11-07)
The role of dopaminergic transmission on striatal mRNA levels of regulators of G protein signalling proteins RGS 2-12 was evaluated by quantitative in situ hybridisation. A single injection of L-dopa (50 mg/kg i.p.) significantly increased the RGS2 mRNA level (by
L-Dopa methyl ester as a new antitumour agent
Wick MM
Nature, 269(5628), 512-513 (1977)
Kevin W McCairn et al.
Journal of neurophysiology, 101(4), 1941-1960 (2009-01-24)
Competing theories seek to account for the therapeutic effects of high-frequency deep brain stimulation (DBS) of the internal globus pallidus (GPi) for medically intractable Parkinson's disease. To investigate this question, we studied the spontaneous activity of 102 pallidal neurons during
Xinxin Yang et al.
International journal of nanomedicine, 7, 2077-2086 (2012-05-24)
Levodopa remains the most effective drug in the treatment of Parkinson's disease. However, long-term administration of levodopa induces motor complications, such as levodopa-induced dyskinesia. The mechanisms underlying levodopa-induced dyskinesia are not fully understood. In this study, we prepared levodopa methyl
The effects of central dopamine function of chronic L-DOPA (methyl ester hydrochloride) treatment of mice
Tabar J, et al.
Pharmacology, Biochemistry, and Behavior, 33(1), 139-146 (1989)
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