D1916

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

Name: 5,6-Dichlorobenzimidazole 1-β-<SC>D</SC>-ribofuranoside
Brand: SIGMA

≥98% (HPLC), powder, RNA synthesis inhibitor

동의어(들):

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₂H₁₂Cl₂N₂O₄

CAS 번호:

53-85-0

Molecular Weight:

319.14

UNSPSC Code:

12352200

eCl@ss:

32151902

PubChem Substance ID:

24278361

NACRES:

NA.77

Beilstein/REAXYS Number:

39123

MDL number:

MFCD00036785

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제품 이름

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside,

Quality Level

200

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23

InChI

1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1

InChI key

XHSQDZXAVJRBMX-DDHJBXDOSA-N

form

powder

storage temp.

−20°C

Gene Information

human ... CSNK2A1(1457), CSNK2B(1460)

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Application

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:

as an inhibitor of RNA polymerase II in mouse melanoma cells
for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines
in the inhibition of interleukin-2 gene transcription in Jurkat cells

Biochem/physiol Actions

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.

Inhibitor of RNA synthesis; causes premature termination of transcription. CK2 (casein kinase-2) inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number

0000420472

0000420473

0000394398

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문서 라이브러리 방문

Muscleblind-like 1 suppresses breast cancer metastatic colonization and stabilizes metastasis suppressor transcripts.

Lisa Fish et al.

Genes & development, 30(4), 386-398 (2016-02-18)

Post-transcriptional deregulation is a defining feature of metastatic cancer. While many microRNAs have been implicated as regulators of metastatic progression, less is known about the roles and mechanisms of RNA-binding proteins in this process. We identified muscleblind-like 1 (MBNL1), a

Inhibition of RNA polymerase II as a trigger for the p53 response.

M Ljungman et al.

Oncogene, 18(3), 583-592 (1999-02-16)

The mechanisms by which the p53 response is triggered following exposure to DNA-damaging agents have not yet been clearly elucidated. We and others have previously suggested that blockage of RNA polymerase II may be the trigger for induction of the

Exploiting native forces to capture chromosome conformation in mammalian cell nuclei.

Lilija Brant et al.

Molecular systems biology, 12(12), 891-891 (2016-12-13)

Mammalian interphase chromosomes fold into a multitude of loops to fit the confines of cell nuclei, and looping is tightly linked to regulated function. Chromosome conformation capture (3C) technology has significantly advanced our understanding of this structure-to-function relationship. However, all

NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation

Yamaguchi Y, et al.

Cell, 97(1), 41-51 (1999)

Rates of in situ transcription and splicing in large human genes

Singh J and Padgett RA

Nature Structural and Molecular Biology, 16(11), 1128-1128 (2009)

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문서

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

≥98% (HPLC), powder, RNA synthesis inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

Quality Level

SMILES string

InChI

InChI key

form

storage temp.

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

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