D2926
Diphenyleneiodonium chloride
≥98%, Nitric oxide synthetase inhibitor, powder
동의어(들):
DPI, Dibenziodolium chloride
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H8ClI
CAS 번호:
Molecular Weight:
314.55
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
Diphenyleneiodonium chloride, ≥98%
SMILES string
[Cl-].[I+]1c2ccccc2-c3ccccc13
InChI
1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
InChI key
FCFZKAVCDNTYID-UHFFFAOYSA-M
assay
≥98%
form
powder
mp
278 °C
solubility
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
storage temp.
room temp
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
mouse ... Pik3r1(18708)
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Application
Diphenyleneiodonium chloride has been used as an NOX inhibitor:
- to study its effects on the reactive oxygen species (ROS) levels and also its inhibitory effects on killing tumor cells by neutrophils isolated from clinical malignant pleural effusion (MPE) samples
- as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor to confirm the variation in inflammation was secondary to overproduction of reactive oxygen species (ROS) in cells treated with doxorubicin (DOX) + flagellin (FL)
- as an NADPH oxidase (NOX) inhibitor to study its effects on palmitate (PA)-induced sphere-forming ability of HepG2 (hepatocellular carcinoma) cells
Biochem/physiol Actions
A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.
A potent reversible nitric oxide synthetase inhibitor from macrophages and endothelial cells.
Diphenyleneiodonium (DPI) can affect mitochondrial function. DPI can block neuron degeneration in Parkinson′s disease. It provides neuroprotection following focal cerebral ischemia. DPI can induce a chemo-quiescence phenotype in cancer stem-like cells, effectively inhibiting their proliferation.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Journal of tissue engineering and regenerative medicine, 10(3), E167-E176 (2013-07-31)
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Scientific reports, 7(1), 16867-16867 (2017-12-06)
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Frontiers in cellular and infection microbiology, 7, 414-414 (2017-10-07)
Neutrophils use different mechanisms to cope with pathogens that invade the host organism. The most intriguing of these responses is a release of neutrophil extracellular traps (NETs) composed of decondensed chromatin and granular proteins with antimicrobial activity. An important potential
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Proceedings of the National Academy of Sciences of the United States of America, 116(33), 16404-16409 (2019-07-31)
Because spermatogonial stem cells (SSCs) are immortal by serial transplantation, SSC aging in intact testes is considered to be caused by a deteriorated microenvironment. Here, we report a cell-intrinsic mode of SSC aging by glycolysis activation. Using cultured SSCs, we
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Redox biology, 14, 72-81 (2017-09-05)
Osteoarthritis (OA) is a degenerative joint disease affecting a large population of people. Although the elevated expression of PKR (double stranded RNA-dependent protein kinase) and MMP-13 (collagenase-3) have been indicated to play pivotal roles in the pathogenesis of OA, the
문서
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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