D4268
NG,NG-Dimethylarginine dihydrochloride
≥98% (TLC), powder, NOS inhibitor
동의어(들):
asym-Dimethylarginine, ADMA
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C8H18N4O2 · 2HCl
CAS 번호:
Molecular Weight:
275.18
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
NG,NG-Dimethylarginine dihydrochloride,
assay
≥98% (TLC)
Quality Level
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
room temp
SMILES string
Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O
InChI
1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
InChI key
SYLNVYJOPZWPJI-ILKKLZGPSA-N
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
General description
NG,NG-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).
Application
NG,NG- Dimethylarginine dihydrochloride has been used:
- to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
- as a standard for measuring L-arginine and dimethylarginines
- to study its effects on hepatic deterioration
Biochem/physiol Actions
Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jasmohan S Bajaj et al.
Gastroenterology, 159(5), 1715-1730 (2020-07-21)
Inpatients with cirrhosis have high rates of acute-on-chronic failure (ACLF) development and high mortality within 30 days of admission to the hospital. Better biomarkers are needed to predict these outcomes. We performed metabolomic analyses of serum samples from patients with
The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine
Okuyucu A, et al.
Turkish Journal of Biology, 40(2), 452-461 (2016)
Tse-Min Lu et al.
Atherosclerosis, 254, 161-166 (2016-10-17)
Decreased nitric oxide (NO) bioavailability and increased oxidative stress may be involved in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The relationship between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and CI-AKI is unknown. We measured plasma ADMA
Gaetano Isola et al.
Journal of periodontology (2020-01-09)
Asymmetric dimethylarginine (ADMA) plays a crucial role in endothelial function and maybe a link for the known interaction of periodontitis and coronary heart disease (CHD). In this pilot study, we compared the impact of gingival health, periodontitis (CP), CHD, or
Monitoring of L-Arginine and Endogenous Dimethylarginines in Survivor Septic Patients-A Pilot Study
Nemeth B, et al.
In Vivo, 30(5), 663-669 (2016)
문서
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
관련 콘텐츠
일산화질소 (NO) 및 세포 스트레스 연구를 위한 생체 활성 저분자
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