D7385

Demecolcine

Name: Demecolcine
Brand: SIGMA

≥98% (HPLC)

동의어(들):

N-Deacetyl-N-methylcolchicine

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₁H₂₅NO₅

CAS 번호:

477-30-5

Molecular Weight:

371.43

UNSPSC Code:

12171500

NACRES:

NA.47

PubChem Substance ID:

24894128

EC Number:

207-514-6

Beilstein/REAXYS Number:

2822892

MDL number:

MFCD00075459

주요 문서

모든 문서 보기

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도움 문의

InChI key

NNJPGOLRFBJNIW-HNNXBMFYSA-N

InChI

1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1

SMILES string

CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13

assay

≥98% (HPLC)

form

powder

mp

184 °C

solubility

chloroform: 10 mg/mL, ethanol: soluble

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

Quality Level

200

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Application

Demecolcine has been used as a microtubule depolymerizing agent. It has also been used to inhibit mitotic division.

Biochem/physiol Actions

Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G₁ and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Lot/Batch Number

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COA 검색

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문서 라이브러리 방문

Flow cytometric discrimination of mitotic nuclei by right-angle light scatter.

Zucker RM, et al.

Cytometry, 9, 226-231 (1988)

The Drosophila microtubule-associated protein mars stabilizes mitotic spindles by crosslinking microtubules through its N-terminal region.

Zhang G, et al.

PLoS ONE, 8, e60596-e60596 (2013)

Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions.

Gang Zhang et al.

Journal of cell science, 122(Pt 4), 535-545 (2009-01-29)

The formation of the mitotic spindle is controlled by the microtubule organizing activity of the centrosomes and by the effects of chromatin-associated Ran-GTP on the activities of spindle assembly factors. In this study we show that Mars, a Drosophila protein

Mammalian chromosomes contain cis-acting elements that control replication timing, mitotic condensation, and stability of entire chromosomes.

Mathew J Thayer

BioEssays : news and reviews in molecular, cellular and developmental biology, 34(9), 760-770 (2012-06-19)

Recent studies indicate that mammalian chromosomes contain discrete cis-acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non-coding RNA gene ASAR6 results in late replication, an under-condensed appearance during mitosis, and structural

Demecolcine- and nocodazole-induced enucleation in mouse and goat oocytes for the preparation of recipient cytoplasts in somatic cell nuclear transfer procedures.

Nuno Costa-Borges et al.

Theriogenology, 75(3), 527-541 (2010-11-16)

Treatment of pre-activated oocytes with demecolcine (DEM) has been shown to induce the extrusion of all oocyte chromosomes within the second polar body (PB2). However, induced enucleation (IE) rates are generally low and the competence of these cytoplasts to support

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Demecolcine

≥98% (HPLC)

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

InChI key

InChI

SMILES string

assay

form

mp

solubility

application(s)

storage temp.

Quality Level

관련 카테고리

설명

Application

Biochem/physiol Actions

Packaging

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

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